Gram H - Search Results

1

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Rucklin G. Revesz L, et al. Among authors: gram h. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3595-9. doi: 10.1016/j.bmcl.2004.03.106. Bioorg Med Chem Lett. 2004. PMID: 15177482

2

SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

Revesz L, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Wolf R, Zimmerlin AG. Revesz L, et al. Among authors: gram h. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2109-12. doi: 10.1016/s0960-894x(02)00336-0. Bioorg Med Chem Lett. 2002. PMID: 12127515

3

SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Rucklin G. Revesz L, et al. Among authors: gram h. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3601-5. doi: 10.1016/j.bmcl.2004.03.111. Bioorg Med Chem Lett. 2004. PMID: 15177483

4

Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

Revesz L, Blum E, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Neumann U, Rucklin G. Revesz L, et al. Among authors: gram h. Bioorg Med Chem Lett. 2006 Jan 15;16(2):262-6. doi: 10.1016/j.bmcl.2005.10.015. Epub 2005 Oct 24. Bioorg Med Chem Lett. 2006. PMID: 16249085

5

SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.

Revesz L, Di Padova FE, Buhl T, Feifel R, Gram H, Hiestand P, Manning U, Zimmerlin AG. Revesz L, et al. Among authors: gram h. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1261-4. doi: 10.1016/s0960-894x(00)00200-6. Bioorg Med Chem Lett. 2000. PMID: 10866395

6

Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.

Brauchle M, Glück D, Di Padova F, Han J, Gram H. Brauchle M, et al. Among authors: gram h. Exp Cell Res. 2000 Jul 10;258(1):135-44. doi: 10.1006/excr.2000.4913. Exp Cell Res. 2000. PMID: 10912795

7

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Schuler W, Bigaud M, Brinkmann V, Di Padova F, Geisse S, Gram H, Hungerford V, Kleuser B, Kristofic C, Menninger K, Tees R, Wieczorek G, Wilt C, Wioland C, Zurini M. Schuler W, et al. Among authors: gram h. Transplantation. 2004 Mar 15;77(5):717-26. doi: 10.1097/01.tp.0000116563.72763.83. Transplantation. 2004. PMID: 15021835

8

Gene suppression by tristetraprolin and release by the p38 pathway.

Zhu W, Brauchle MA, Di Padova F, Gram H, New L, Ono K, Downey JS, Han J. Zhu W, et al. Among authors: gram h. Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L499-508. doi: 10.1152/ajplung.2001.281.2.L499. Am J Physiol Lung Cell Mol Physiol. 2001. PMID: 11435226 Free article.

9

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. Ge B, et al. Among authors: gram h. Science. 2002 Feb 15;295(5558):1291-4. doi: 10.1126/science.1067289. Science. 2002. PMID: 11847341

10

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MM, Di Padova FE, Boots AM, Gram H, Joosten LA, van den Berg WB. Koenders MI, et al. Among authors: gram h. Am J Pathol. 2005 Jul;167(1):141-9. doi: 10.1016/S0002-9440(10)62961-6. Am J Pathol. 2005. PMID: 15972960 Free PMC article.

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