Berge JM - Search Results

1

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41. doi: 10.1016/j.bmcl.2004.05.070. Bioorg Med Chem Lett. 2004. PMID: 15225702

2

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A. Jarvest RL, et al. Among authors: berge jm. J Med Chem. 2002 May 9;45(10):1959-62. doi: 10.1021/jm025502x. J Med Chem. 2002. PMID: 11985462

3

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8. doi: 10.1016/s0960-894x(02)01027-2. Bioorg Med Chem Lett. 2003. PMID: 12639554

4

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8. doi: 10.1016/s0960-894x(03)00093-3. Bioorg Med Chem Lett. 2003. PMID: 12657260

5

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

Berge JM, Copley RC, Eggleston DS, Hamprecht DW, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ. Berge JM, et al. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1811-4. doi: 10.1016/s0960-894x(00)00348-6. Bioorg Med Chem Lett. 2000. PMID: 10969974

6

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

Berge JM, Broom NJ, Houge-Frydrych CS, Jarvest RL, Mensah L, McNair DJ, O'Hanlon PJ, Pope AJ, Rittenhouse S. Berge JM, et al. J Antibiot (Tokyo). 2000 Nov;53(11):1282-92. doi: 10.7164/antibiotics.53.1282. J Antibiot (Tokyo). 2000. PMID: 11213289 Free article.

7

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

Jarvest RL, Berge JM, Brown P, Hamprecht DW, McNair DJ, Mensah L, O'Hanlon PJ, Pope AJ. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 2001 Mar 12;11(5):715-8. doi: 10.1016/s0960-894x(01)00040-3. Bioorg Med Chem Lett. 2001. PMID: 11266176

8

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

Jarvest RL, Berge JM, Houge-Frydrych CS, Mensah LM, O'Hanlon PJ, Pope AJ. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2499-502. doi: 10.1016/s0960-894x(01)00475-9. Bioorg Med Chem Lett. 2001. PMID: 11549455

9

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Jarvest RL, Berge JM, Houge-Frydrych CS, Janson C, Mensah LM, O'Hanlon PJ, Pope A, Saldanha A, Qiu X. Jarvest RL, et al. Among authors: berge jm. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62. doi: 10.1016/s0960-894x(99)00488-6. Bioorg Med Chem Lett. 1999. PMID: 10522706

10

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL. Qiu X, et al. Protein Sci. 2001 Oct;10(10):2008-16. doi: 10.1110/ps.18001. Protein Sci. 2001. PMID: 11567092 Free PMC article.

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