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Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424).
Leadbetter MR, Adams SM, Bazzini B, Fatheree PR, Karr DE, Krause KM, Lam BM, Linsell MS, Nodwell MB, Pace JL, Quast K, Shaw JP, Soriano E, Trapp SG, Villena JD, Wu TX, Christensen BG, Judice JK. Leadbetter MR, et al. Among authors: pace jl. J Antibiot (Tokyo). 2004 May;57(5):326-36. doi: 10.7164/antibiotics.57.326. J Antibiot (Tokyo). 2004. PMID: 15303493 Free article.
In vitro activity of TD-6424 against Staphylococcus aureus.
Pace JL, Krause K, Johnston D, Debabov D, Wu T, Farrington L, Lane C, Higgins DL, Christensen B, Judice JK, Kaniga K. Pace JL, et al. Antimicrob Agents Chemother. 2003 Nov;47(11):3602-4. doi: 10.1128/AAC.47.11.3602-3604.2003. Antimicrob Agents Chemother. 2003. PMID: 14576125 Free PMC article.
Semi-synthetic glycopeptide antibacterials.
Judice JK, Pace JL. Judice JK, et al. Among authors: pace jl. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4165-8. doi: 10.1016/j.bmcl.2003.08.067. Bioorg Med Chem Lett. 2003. PMID: 14622994 Review.
Vancomycin disulfide derivatives as antibacterial agents.
Mu Y, Nodwell M, Pace JL, Shaw JP, Judice JK. Mu Y, et al. Among authors: pace jl. Bioorg Med Chem Lett. 2004 Feb 9;14(3):735-8. doi: 10.1016/j.bmcl.2003.11.040. Bioorg Med Chem Lett. 2004. PMID: 14741279
A multivalent approach to drug discovery for novel antibiotics.
Long DD, Aggen JB, Christensen BG, Judice JK, Hegde SS, Kaniga K, Krause KM, Linsell MS, Moran EJ, Pace JL. Long DD, et al. Among authors: pace jl. J Antibiot (Tokyo). 2008 Oct;61(10):595-602. doi: 10.1038/ja.2008.79. J Antibiot (Tokyo). 2008. PMID: 19168973
Exploring the positional attachment of glycopeptide/beta-lactam heterodimers.
Long DD, Aggen JB, Chinn J, Choi SK, Christensen BG, Fatheree PR, Green D, Hegde SS, Judice JK, Kaniga K, Krause KM, Leadbetter M, Linsell MS, Marquess DG, Moran EJ, Nodwell MB, Pace JL, Trapp SG, Turner SD. Long DD, et al. Among authors: pace jl. J Antibiot (Tokyo). 2008 Oct;61(10):603-14. doi: 10.1038/ja.2008.80. J Antibiot (Tokyo). 2008. PMID: 19168974
Telavancin (Theravance).
Pace JL, Judice JK. Pace JL, et al. Curr Opin Investig Drugs. 2005 Feb;6(2):216-25. Curr Opin Investig Drugs. 2005. PMID: 15751746 Review.
Approved Glycopeptide Antibacterial Drugs: Mechanism of Action and Resistance.
Zeng D, Debabov D, Hartsell TL, Cano RJ, Adams S, Schuyler JA, McMillan R, Pace JL. Zeng D, et al. Among authors: pace jl. Cold Spring Harb Perspect Med. 2016 Dec 1;6(12):a026989. doi: 10.1101/cshperspect.a026989. Cold Spring Harb Perspect Med. 2016. PMID: 27663982 Free PMC article. Review.
191 results