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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.
Kalia NP, Hasenoehrl EJ, Ab Rahman NB, Koh VH, Ang MLT, Sajorda DR, Hards K, Grüber G, Alonso S, Cook GM, Berney M, Pethe K. Kalia NP, et al. Among authors: pethe k. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7426-7431. doi: 10.1073/pnas.1706139114. Epub 2017 Jun 26. Proc Natl Acad Sci U S A. 2017. PMID: 28652330 Free PMC article.
HflX is a GTPase that controls hypoxia-induced replication arrest in slow-growing mycobacteria.
Ngan JYG, Pasunooti S, Tse W, Meng W, Ngan SFC, Jia H, Lin JQ, Ng SW, Jaafa MT, Cho SLS, Lim J, Koh HQV, Abdul Ghani N, Pethe K, Sze SK, Lescar J, Alonso S. Ngan JYG, et al. Among authors: pethe k. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2006717118. doi: 10.1073/pnas.2006717118. Proc Natl Acad Sci U S A. 2021. PMID: 33723035 Free PMC article.
120 results