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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. Among authors: bush ai. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Puglielli L, et al. Among authors: bush ai. J Clin Invest. 2005 Sep;115(9):2556-63. doi: 10.1172/JCI23610. Epub 2005 Aug 25. J Clin Invest. 2005. PMID: 16127459 Free PMC article.
Copper: from neurotransmission to neuroproteostasis.
Opazo CM, Greenough MA, Bush AI. Opazo CM, et al. Among authors: bush ai. Front Aging Neurosci. 2014 Jul 3;6:143. doi: 10.3389/fnagi.2014.00143. eCollection 2014. Front Aging Neurosci. 2014. PMID: 25071552 Free PMC article. Review.
Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons.
Castro PA, Ramirez A, Sepúlveda FJ, Peters C, Fierro H, Waldron J, Luza S, Fuentealba J, Muñoz FJ, De Ferrari GV, Bush AI, Aguayo LG, Opazo CM. Castro PA, et al. Among authors: bush ai. Front Aging Neurosci. 2014 Dec 3;6:319. doi: 10.3389/fnagi.2014.00319. eCollection 2014. Front Aging Neurosci. 2014. PMID: 25520655 Free PMC article.
Redox active metals in neurodegenerative diseases.
Acevedo K, Masaldan S, Opazo CM, Bush AI. Acevedo K, et al. Among authors: bush ai. J Biol Inorg Chem. 2019 Dec;24(8):1141-1157. doi: 10.1007/s00775-019-01731-9. Epub 2019 Oct 24. J Biol Inorg Chem. 2019. PMID: 31650248 Review.
490 results