Lunney EA - Search Results

1

Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.

Repine JT, Kaltenbronn JS, Doherty AM, Hamby JM, Himmelsbach RJ, Kornberg BE, Taylor MD, Lunney EA, Humblet C, Rapundalo ST, et al. Repine JT, et al. Among authors: lunney ea. J Med Chem. 1992 Mar 20;35(6):1032-42. doi: 10.1021/jm00084a008. J Med Chem. 1992. PMID: 1552498

2

Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.

Repine JT, Himmelsbach RJ, Hodges JC, Kaltenbronn JS, Sircar I, Skeean RW, Brennan ST, Hurley TR, Lunney E, Humblet CC, et al. Repine JT, et al. J Med Chem. 1991 Jul;34(7):1935-43. doi: 10.1021/jm00111a002. J Med Chem. 1991. PMID: 2066966

3

Molecular modeling of renin inhibitor P2 substituents.

Lunney EA, Humblet CC, Repine JT, Blundell TL, Cooper JB, Sibanda BL. Lunney EA, et al. Adv Exp Med Biol. 1991;306:391-4. doi: 10.1007/978-1-4684-6012-4_51. Adv Exp Med Biol. 1991. PMID: 1812735 No abstract available.

4

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites.

Kaltenbronn JS, Hudspeth JP, Lunney EA, Michniewicz BM, Nicolaides ED, Repine JT, RoarK WH, Stier MA, Tinney FJ, Woo PK, et al. Kaltenbronn JS, et al. Among authors: lunney ea. J Med Chem. 1990 Feb;33(2):838-45. doi: 10.1021/jm00164a058. J Med Chem. 1990. PMID: 2405159

5

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM, et al. Plummer MS, et al. Among authors: lunney ea. J Med Chem. 1995 Jul 21;38(15):2893-905. doi: 10.1021/jm00015a012. J Med Chem. 1995. PMID: 7636850

6

Nonpeptidic potent HIV-1 protease inhibitors: (4-hydroxy-6-phenyl-2-oxo-2H- pyran-3-yl)thiomethanes that span P1-P2' subsites in a unique mode of active site binding.

Prasad JV, Para KS, Tummino PJ, Ferguson D, McQuade TJ, Lunney EA, Rapundalo ST, Batley BL, Hingorani G, Domagala JM, et al. Prasad JV, et al. Among authors: lunney ea. J Med Chem. 1995 Mar 17;38(6):898-905. doi: 10.1021/jm00006a007. J Med Chem. 1995. PMID: 7699705

7

Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.

Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT, et al. Lunney EA, et al. J Med Chem. 1993 Nov 26;36(24):3809-20. doi: 10.1021/jm00076a008. J Med Chem. 1993. PMID: 8254610

8

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. Rao CM, et al. Among authors: lunney ea. J Med Chem. 1993 Sep 3;36(18):2614-20. doi: 10.1021/jm00070a004. J Med Chem. 1993. PMID: 8410973

9

Modified di- and tripeptides of the C-terminal portion of oxytocin and vasopressin as possible cognition activation agents.

Nicolaides ED, Tinney FJ, Kaltenbronn JS, Repine JT, DeJohn DA, Lunney EA, Roark WH, Marriott JG, Davis RE, Voigtman RE. Nicolaides ED, et al. Among authors: lunney ea. J Med Chem. 1986 Jun;29(6):959-71. doi: 10.1021/jm00156a012. J Med Chem. 1986. PMID: 3712386

10

A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.

Lunney EA, Hagen SE, Domagala JM, Humblet C, Kosinski J, Tait BD, Warmus JS, Wilson M, Ferguson D, Hupe D, et al. Lunney EA, et al. J Med Chem. 1994 Aug 19;37(17):2664-77. doi: 10.1021/jm00043a006. J Med Chem. 1994. PMID: 8064795

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