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Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
Xu Q, Takekida S, Ohara N, Chen W, Sitruk-Ware R, Johansson ED, Maruo T. Xu Q, et al. Among authors: ohara n. J Clin Endocrinol Metab. 2005 Feb;90(2):953-61. doi: 10.1210/jc.2004-1569. Epub 2004 Nov 30. J Clin Endocrinol Metab. 2005. PMID: 15572421
Gonadotropin-releasing hormone antagonist cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human leiomyoma cells.
Chen W, Yoshida S, Ohara N, Matsuo H, Morizane M, Maruo T. Chen W, et al. Among authors: ohara n. J Clin Endocrinol Metab. 2005 Feb;90(2):884-92. doi: 10.1210/jc.2004-1591. Epub 2004 Nov 9. J Clin Endocrinol Metab. 2005. PMID: 15536154
A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T. Chen W, et al. Among authors: ohara n. J Clin Endocrinol Metab. 2006 Apr;91(4):1296-304. doi: 10.1210/jc.2005-2379. Epub 2006 Feb 7. J Clin Endocrinol Metab. 2006. PMID: 16464945
A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
Sasaki H, Ohara N, Xu Q, Wang J, DeManno DA, Chwalisz K, Yoshida S, Maruo T. Sasaki H, et al. Among authors: ohara n. J Clin Endocrinol Metab. 2007 Feb;92(2):616-23. doi: 10.1210/jc.2006-0898. Epub 2006 Nov 14. J Clin Endocrinol Metab. 2007. PMID: 17105846
905 results