Elokdah H - Search Results

1

Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling.

Weisberg AD, Albornoz F, Griffin JP, Crandall DL, Elokdah H, Fogo AB, Vaughan DE, Brown NJ. Weisberg AD, et al. Among authors: elokdah h. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):365-71. doi: 10.1161/01.ATV.0000152356.85791.52. Epub 2004 Dec 2. Arterioscler Thromb Vasc Biol. 2005. PMID: 15576638

2

Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis.

Smith LH, Dixon JD, Stringham JR, Eren M, Elokdah H, Crandall DL, Washington K, Vaughan DE. Smith LH, et al. Among authors: elokdah h. Blood. 2006 Jan 1;107(1):132-4. doi: 10.1182/blood-2005-07-2681. Epub 2005 Sep 13. Blood. 2006. PMID: 16160004 Free PMC article.

3

Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.

Elokdah H, Abou-Gharbia M, Hennan JK, McFarlane G, Mugford CP, Krishnamurthy G, Crandall DL. Elokdah H, et al. J Med Chem. 2004 Jul 1;47(14):3491-4. doi: 10.1021/jm049766q. J Med Chem. 2004. PMID: 15214776

4

Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis.

Hennan JK, Elokdah H, Leal M, Ji A, Friedrichs GS, Morgan GA, Swillo RE, Antrilli TM, Hreha A, Crandall DL. Hennan JK, et al. Among authors: elokdah h. J Pharmacol Exp Ther. 2005 Aug;314(2):710-6. doi: 10.1124/jpet.105.084129. Epub 2005 Apr 28. J Pharmacol Exp Ther. 2005. PMID: 15860572

5

Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.

Gorlatova NV, Cale JM, Elokdah H, Li D, Fan K, Warnock M, Crandall DL, Lawrence DA. Gorlatova NV, et al. Among authors: elokdah h. J Biol Chem. 2007 Mar 23;282(12):9288-96. doi: 10.1074/jbc.M611642200. Epub 2007 Feb 2. J Biol Chem. 2007. PMID: 17276980 Free article.

6

Dose-dependent thrombus resolution due to oral plaminogen activator inhibitor (PAI)-1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis.

Baxi S, Crandall DL, Meier TR, Wrobleski S, Hawley A, Farris D, Elokdah H, Sigler R, Schaub RG, Wakefield T, Myers D. Baxi S, et al. Among authors: elokdah h. Thromb Haemost. 2008 Apr;99(4):749-58. doi: 10.1160/TH07-11-0669. Thromb Haemost. 2008. PMID: 18392333

7

Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function.

Gorlatova NV, Elokdah H, Fan K, Crandall DL, Lawrence DA. Gorlatova NV, et al. Among authors: elokdah h. J Biol Chem. 2003 May 2;278(18):16329-35. doi: 10.1074/jbc.M208420200. Epub 2003 Feb 26. J Biol Chem. 2003. PMID: 12606560 Free article.

8

Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action.

Gardell SJ, Krueger JA, Antrilli TA, Elokdah H, Mayer S, Orcutt SJ, Crandall DL, Vlasuk GP. Gardell SJ, et al. Among authors: elokdah h. Mol Pharmacol. 2007 Oct;72(4):897-906. doi: 10.1124/mol.107.037010. Epub 2007 Jul 10. Mol Pharmacol. 2007. PMID: 17622579

9

WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation.

Crandall DL, Hennan JK, Elokdah H, Krishnamurthy G, Antrilli TM, Bauer JS, Morgan GA, Swillo RE. Crandall DL, et al. Among authors: elokdah h. Biochem Biophys Res Commun. 2003 Nov 28;311(4):904-8. doi: 10.1016/j.bbrc.2003.10.088. Biochem Biophys Res Commun. 2003. PMID: 14623266

10

Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy.

Crandall DL, Elokdah H, Di L, Hennan JK, Gorlatova NV, Lawrence DA. Crandall DL, et al. Among authors: elokdah h. J Thromb Haemost. 2004 Aug;2(8):1422-8. doi: 10.1111/j.1538-7836.2004.00829.x. J Thromb Haemost. 2004. PMID: 15304050 Free article.

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