Kayakiri H - Search Results

1

Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.

Nakajima Y, Hamashima H, Washizuka K, Tomishima Y, Ohtake H, Imamura E, Miura T, Kayakiri H, Kato M. Nakajima Y, et al. Among authors: kayakiri h. Bioorg Med Chem Lett. 2005 Jan 17;15(2):251-4. doi: 10.1016/j.bmcl.2004.11.001. Bioorg Med Chem Lett. 2005. PMID: 15603933

2

Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Hatori C, Aramori I, Oku T, Tanaka H. Sawada Y, et al. Among authors: kayakiri h. J Med Chem. 2004 May 20;47(11):2853-63. doi: 10.1021/jm030468n. J Med Chem. 2004. PMID: 15139763

3

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Aramori I, Hatori C, Sawai H, Oku T, Tanaka H. Abe Y, et al. Among authors: kayakiri h. J Med Chem. 1998 Nov 5;41(23):4587-98. doi: 10.1021/jm980330i. J Med Chem. 1998. PMID: 9804698

4

A new class of nonpeptide bradykinin B(2) receptor ligand, incorporating a 4-aminoquinoline framework. Identification of a key pharmacophore to determine species difference and agonist/antagonist profile.

Sawada Y, Kayakiri H, Abe Y, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Oku T, Tanaka H. Sawada Y, et al. Among authors: kayakiri h. J Med Chem. 2004 May 6;47(10):2667-77. doi: 10.1021/jm030326t. J Med Chem. 2004. PMID: 15115408

5

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 3. Discovering bioisosteres of the imidazo[1,2-a] pyridine moiety.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Aramori I, Hatori C, Sawai H, Oku T, Tanaka H. Abe Y, et al. Among authors: kayakiri h. J Med Chem. 1998 Oct 8;41(21):4062-79. doi: 10.1021/jm980300f. J Med Chem. 1998. PMID: 9767643

6

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 1. Construction of the basic framework.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Imai K, Inamura N, Asano M, Hatori C, Katayama A, Oku T, Tanaka H. Abe Y, et al. Among authors: kayakiri h. J Med Chem. 1998 Feb 12;41(4):564-78. doi: 10.1021/jm970591c. J Med Chem. 1998. PMID: 9484506

7

A new series of highly potent non-peptide bradykinin B2 receptor antagonists incorporating the 4-heteroarylquinoline framework. Improvement of aqueous solubility and new insights into species difference.

Sawada Y, Kayakiri H, Abe Y, Imai K, Mizutani T, Inamura N, Asano M, Aramori I, Hatori C, Katayama A, Oku T, Tanaka H. Sawada Y, et al. Among authors: kayakiri h. J Med Chem. 2004 Mar 25;47(7):1617-30. doi: 10.1021/jm030159x. J Med Chem. 2004. PMID: 15027853

8

A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 2. Overcoming the species difference between guinea pig and man.

Abe Y, Kayakiri H, Satoh S, Inoue T, Sawada Y, Inamura N, Asano M, Hatori C, Sawai H, Oku T, Tanaka H. Abe Y, et al. Among authors: kayakiri h. J Med Chem. 1998 Oct 8;41(21):4053-61. doi: 10.1021/jm980214f. J Med Chem. 1998. PMID: 9767642

9

Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.

Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R. Calderon SN, et al. Among authors: kayakiri h. J Med Chem. 1997 Feb 28;40(5):695-704. doi: 10.1021/jm960319n. J Med Chem. 1997. PMID: 9057856

10

Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.

Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F. Zhang X, et al. Among authors: kayakiri h. J Med Chem. 1999 Dec 30;42(26):5455-63. doi: 10.1021/jm9903895. J Med Chem. 1999. PMID: 10639287

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