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Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo.
Hamasaki M, Hideshima T, Tassone P, Neri P, Ishitsuka K, Yasui H, Shiraishi N, Raje N, Kumar S, Picker DH, Jacob GS, Richardson PG, Munshi NC, Anderson KC. Hamasaki M, et al. Blood. 2005 Jun 1;105(11):4470-6. doi: 10.1182/blood-2004-09-3794. Epub 2005 Feb 10. Blood. 2005. PMID: 15705788 Free PMC article.
Biological pathways and in vivo antitumor activity induced by Atiprimod in myeloma.
Neri P, Tassone P, Shammas M, Yasui H, Schipani E, Batchu RB, Blotta S, Prabhala R, Catley L, Hamasaki M, Hideshima T, Chauhan D, Jacob GS, Picker D, Venuta S, Anderson KC, Munshi NC. Neri P, et al. Among authors: hamasaki m. Leukemia. 2007 Dec;21(12):2519-26. doi: 10.1038/sj.leu.2404912. Epub 2007 Sep 20. Leukemia. 2007. PMID: 17882285
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Hayashi T, Hideshima T, Nguyen AN, Munoz O, Podar K, Hamasaki M, Ishitsuka K, Yasui H, Richardson P, Chakravarty S, Murphy A, Chauhan D, Higgins LS, Anderson KC. Hayashi T, et al. Among authors: hamasaki m. Clin Cancer Res. 2004 Nov 15;10(22):7540-6. doi: 10.1158/1078-0432.CCR-04-0632. Clin Cancer Res. 2004. PMID: 15569984
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Yasui H, Hideshima T, Hamasaki M, Roccaro AM, Shiraishi N, Kumar S, Tassone P, Ishitsuka K, Raje N, Tai YT, Podar K, Chauhan D, Leoni LM, Kanekal S, Elliott G, Munshi NC, Anderson KC. Yasui H, et al. Among authors: hamasaki m. Blood. 2005 Jul 15;106(2):706-12. doi: 10.1182/blood-2005-02-0838. Epub 2005 Mar 31. Blood. 2005. PMID: 15802527 Free PMC article.
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Ishitsuka K, Hideshima T, Hamasaki M, Raje N, Kumar S, Hideshima H, Shiraishi N, Yasui H, Roccaro AM, Richardson P, Podar K, Le Gouill S, Chauhan D, Tamura K, Arbiser J, Anderson KC. Ishitsuka K, et al. Among authors: hamasaki m. Blood. 2005 Sep 1;106(5):1794-800. doi: 10.1182/blood-2005-01-0346. Epub 2005 May 3. Blood. 2005. PMID: 15870175 Free PMC article.
Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.
Ishitsuka K, Hideshima T, Hamasaki M, Raje N, Kumar S, Podar K, Le Gouill S, Shiraishi N, Yasui H, Roccaro AM, Tai YZ, Chauhan D, Fram R, Tamura K, Jain J, Anderson KC. Ishitsuka K, et al. Among authors: hamasaki m. Oncogene. 2005 Sep 1;24(38):5888-96. doi: 10.1038/sj.onc.1208739. Oncogene. 2005. PMID: 15940263
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, Anderson KC. Yasui H, et al. Among authors: hamasaki m. Cancer Res. 2005 Aug 15;65(16):7478-84. doi: 10.1158/0008-5472.CAN-05-0850. Cancer Res. 2005. PMID: 16103102
280 results