Hoekstra WJ - Search Results

1

Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.

Hoekstra WJ, Patel HS, Liang X, Blanc JB, Heyer DO, Willson TM, Iannone MA, Kadwell SH, Miller LA, Pearce KH, Simmons CA, Shearin J. Hoekstra WJ, et al. J Med Chem. 2005 Mar 24;48(6):2243-7. doi: 10.1021/jm040154f. J Med Chem. 2005. PMID: 15771467

2

Design and synthesis of an array of selective androgen receptor modulators.

Trump RP, Blanc JB, Stewart EL, Brown PJ, Caivano M, Gray DW, Hoekstra WJ, Willson TM, Han B, Turnbull P. Trump RP, et al. Among authors: hoekstra wj. J Comb Chem. 2007 Jan-Feb;9(1):107-14. doi: 10.1021/cc060096e. J Comb Chem. 2007. PMID: 17206838

3

Co-crystal structure guided array synthesis of PPARgamma inverse agonists.

Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ. Trump RP, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. doi: 10.1016/j.bmcl.2007.04.111. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17533125

4

Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists.

Jones DG, Liang X, Stewart EL, Noe RA, Kallander LS, Madauss KP, Williams SP, Thompson SK, Gray DW, Hoekstra WJ. Jones DG, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3203-6. doi: 10.1016/j.bmcl.2005.05.001. Bioorg Med Chem Lett. 2005. PMID: 15925510

5

The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox.

Hoekstra WJ. Hoekstra WJ. Curr Med Chem. 2001 May;8(6):715-9. doi: 10.2174/0929867013373192. Curr Med Chem. 2001. PMID: 11281850 Review.

6

Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines.

Wiethe RW, Stewart EL, Drewry DH, Gray DW, Mehbob A, Hoekstra WJ. Wiethe RW, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3777-9. doi: 10.1016/j.bmcl.2006.04.055. Epub 2006 May 5. Bioorg Med Chem Lett. 2006. PMID: 16678409

7

Recent advances in peroxisome proliferator-activated receptor science.

Shearer BG, Hoekstra WJ. Shearer BG, et al. Among authors: hoekstra wj. Curr Med Chem. 2003 Feb;10(4):267-80. doi: 10.2174/0929867033368295. Curr Med Chem. 2003. PMID: 12570700 Review.

8

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

Zhang HC, Derian CK, Andrade-Gordon P, Hoekstra WJ, McComsey DF, White KB, Poulter BL, Addo MF, Cheung WM, Damiano BP, Oksenberg D, Reynolds EE, Pandey A, Scarborough RM, Maryanoff BE. Zhang HC, et al. Among authors: hoekstra wj. J Med Chem. 2001 Mar 29;44(7):1021-4. doi: 10.1021/jm000506s. J Med Chem. 2001. PMID: 11297447 No abstract available.

9

Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.

Matthews JM, Greco MN, Hecker LR, Hoekstra WJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Maryanoff BE. Matthews JM, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2003 Feb 24;13(4):753-6. doi: 10.1016/s0960-894x(02)01059-4. Bioorg Med Chem Lett. 2003. PMID: 12639574

10

Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.

Matthews JM, Hoekstra WJ, Dyatkin AB, Hecker LR, Hlasta DJ, Poulter BL, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Reynolds CH, Maryanoff BE. Matthews JM, et al. Among authors: hoekstra wj. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2747-52. doi: 10.1016/j.bmcl.2004.03.083. Bioorg Med Chem Lett. 2004. PMID: 15125926

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