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The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors.
Balzarini J, Auwerx J, Rodríguez-Barrios F, Chedad A, Farkas V, Ceccherini-Silberstein F, García-Aparicio C, Velázquez S, De Clercq E, Perno CF, Camarasa MJ, Gago F. Balzarini J, et al. Mol Pharmacol. 2005 Jul;68(1):49-60. doi: 10.1124/mol.105.012435. Epub 2005 Apr 15. Mol Pharmacol. 2005. PMID: 15833734
Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.
Sánchez-Murcia PA, de Castro S, García-Aparicio C, Jiménez MA, Corona A, Tramontano E, Sluis-Cremer N, Menéndez-Arias L, Velázquez S, Gago F, Camarasa MJ. Sánchez-Murcia PA, et al. Among authors: garcia aparicio c. ACS Med Chem Lett. 2020 Jan 24;11(5):811-817. doi: 10.1021/acsmedchemlett.9b00623. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435389 Free PMC article.
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