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PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo.
Rudin M, McSheehy PM, Allegrini PR, Rausch M, Baumann D, Becquet M, Brecht K, Brueggen J, Ferretti S, Schaeffer F, Schnell C, Wood J. Rudin M, et al. Among authors: mcsheehy pm. NMR Biomed. 2005 Aug;18(5):308-21. doi: 10.1002/nbm.961. NMR Biomed. 2005. PMID: 15918178
AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity.
Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, Meyer T, Tang C, Wartmann M, Wood J, Caravatti G. Traxler P, et al. Cancer Res. 2004 Jul 15;64(14):4931-41. doi: 10.1158/0008-5472.CAN-03-3681. Cancer Res. 2004. PMID: 15256466
Minimally invasive biomarkers for therapy monitoring.
McSheehy P, Allegrini P, Ametaby S, Becquet M, Ebenhan T, Honer M, Ferretti S, Lane H, Schubiger P, Schnell C, Stumm M, Wood J. McSheehy P, et al. Ernst Schering Found Symp Proc. 2007;(4):153-88. doi: 10.1007/2789_2008_093. Ernst Schering Found Symp Proc. 2007. PMID: 18811057
Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases.
Lee L, Sharma S, Morgan B, Allegrini P, Schnell C, Brueggen J, Cozens R, Horsfield M, Guenther C, Steward WP, Drevs J, Lebwohl D, Wood J, McSheehy PM. Lee L, et al. Among authors: mcsheehy pm. Cancer Chemother Pharmacol. 2006 Jun;57(6):761-71. doi: 10.1007/s00280-005-0120-6. Epub 2005 Sep 20. Cancer Chemother Pharmacol. 2006. PMID: 16172907 Clinical Trial.
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging.
Schnell CR, Stauffer F, Allegrini PR, O'Reilly T, McSheehy PM, Dartois C, Stumm M, Cozens R, Littlewood-Evans A, García-Echeverría C, Maira SM. Schnell CR, et al. Among authors: mcsheehy pm. Cancer Res. 2008 Aug 15;68(16):6598-607. doi: 10.1158/0008-5472.CAN-08-1044. Cancer Res. 2008. PMID: 18701483
71 results