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Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells.
Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. Napoletano C, et al. Cancer Res. 2007 Sep 1;67(17):8358-67. doi: 10.1158/0008-5472.CAN-07-1035. Cancer Res. 2007. PMID: 17804752 Free article.
Microvesicle cargo of tumor-associated MUC1 to dendritic cells allows cross-presentation and specific carbohydrate processing.
Rughetti A, Rahimi H, Belleudi F, Napoletano C, Battisti F, Zizzari IG, Antonilli M, Bellati F, Wandall HH, Benedetti Panici P, Burchell JM, Torrisi MR, Nuti M. Rughetti A, et al. Among authors: burchell jm. Cancer Immunol Res. 2014 Feb;2(2):177-86. doi: 10.1158/2326-6066.CIR-13-0112-T. Epub 2013 Oct 28. Cancer Immunol Res. 2014. PMID: 24778281
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.
Sewell R, Bäckström M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gätgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J. Sewell R, et al. J Biol Chem. 2006 Feb 10;281(6):3586-94. doi: 10.1074/jbc.M511826200. Epub 2005 Nov 30. J Biol Chem. 2006. PMID: 16319059 Free article.
136 results