Danks MK - Search Results

1

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. Among authors: danks mk. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

2

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism.

Yoon KJ, Morton CL, Potter PM, Danks MK, Lee RE. Yoon KJ, et al. Among authors: danks mk. Bioorg Med Chem. 2003 Jul 31;11(15):3237-44. doi: 10.1016/s0968-0896(03)00302-x. Bioorg Med Chem. 2003. PMID: 12837533

3

Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.

Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK. Yoon KJ, et al. Among authors: danks mk. Mol Cancer Ther. 2004 Aug;3(8):903-9. Mol Cancer Ther. 2004. PMID: 15299073

4

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: danks mk. J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j. J Med Chem. 2005. PMID: 15828829

5

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM. Hyatt JL, et al. Among authors: danks mk. Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160. Mol Cancer Ther. 2006. PMID: 16985062

6

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: danks mk. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

7

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Hyatt JL, et al. Among authors: danks mk. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941623

8

Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.

Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK. Yoon KJ, et al. Among authors: danks mk. Mol Cancer Ther. 2003 Nov;2(11):1171-81. Mol Cancer Ther. 2003. PMID: 14617791

9

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM. Wierdl M, et al. Among authors: danks mk. J Pharmacol Exp Ther. 2003 Feb;304(2):699-705. doi: 10.1124/jpet.102.044149. J Pharmacol Exp Ther. 2003. PMID: 12538824

10

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM. Wierdl M, et al. Among authors: danks mk. Mol Pharmacol. 2003 Aug;64(2):279-88. doi: 10.1124/mol.64.2.279. Mol Pharmacol. 2003. PMID: 12869632

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