Tam S - Search Results

1

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

Xiang JS, Hu Y, Rush TS, Thomason JR, Ipek M, Sum PE, Abrous L, Sabatini JJ, Georgiadis K, Reifenberg E, Majumdar M, Morris EA, Tam S. Xiang JS, et al. Among authors: tam s. Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. doi: 10.1016/j.bmcl.2005.10.001. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275085

2

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

Gavrin LK, Green N, Hu Y, Janz K, Kaila N, Li HQ, Tam SY, Thomason JR, Gopalsamy A, Ciszewski G, Cuozzo JW, Hall JP, Hsu S, Telliez JB, Lin LL. Gavrin LK, et al. Among authors: tam sy. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. doi: 10.1016/j.bmcl.2005.08.029. Epub 2005 Sep 13. Bioorg Med Chem Lett. 2005. PMID: 16165349

3

Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Xiang J, Ipek M, Suri V, Massefski W, Pan N, Ge Y, Tam M, Xing Y, Tobin JF, Xu X, Tam S. Xiang J, et al. Among authors: tam s, tam m. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2865-9. doi: 10.1016/j.bmcl.2005.03.093. Bioorg Med Chem Lett. 2005. PMID: 15911270

4

Synthesis and SAR of highly selective MMP-13 inhibitors.

Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI. Li J, et al. Among authors: tam s. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. doi: 10.1016/j.bmcl.2005.08.001. Bioorg Med Chem Lett. 2005. PMID: 16153831

5

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

Hu Y, Xiang JS, DiGrandi MJ, Du X, Ipek M, Laakso LM, Li J, Li W, Rush TS, Schmid J, Skotnicki JS, Tam S, Thomason JR, Wang Q, Levin JI. Hu Y, et al. Among authors: tam s. Bioorg Med Chem. 2005 Dec 15;13(24):6629-44. doi: 10.1016/j.bmc.2005.07.076. Epub 2005 Oct 10. Bioorg Med Chem. 2005. PMID: 16216515

6

3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.

Li W, Hu Y, Li J, Thomason JR, DeVincentis D, Du X, Wu J, Hotchandani R, Rush TS 3rd, Skotnicki JS, Tam S, Chockalingam PS, Morris EA, Levin JI. Li W, et al. Among authors: tam s. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4546-50. doi: 10.1016/j.bmcl.2009.07.008. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19625186

7

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

Hu Y, Xing L, Thomason JR, Xiang J, Ipek M, Guler S, Li H, Sabatini J, Chockalingam P, Reifenberg E, Sheldon R, Morris EA, Georgiadis KE, Tam S. Hu Y, et al. Among authors: tam s. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6800-3. doi: 10.1016/j.bmcl.2011.09.036. Epub 2011 Sep 18. Bioorg Med Chem Lett. 2011. PMID: 21982494

8

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

Green N, Hu Y, Janz K, Li HQ, Kaila N, Guler S, Thomason J, Joseph-McCarthy D, Tam SY, Hotchandani R, Wu J, Huang A, Wang Q, Leung L, Pelker J, Marusic S, Hsu S, Telliez JB, Hall JP, Cuozzo JW, Lin LL. Green N, et al. Among authors: tam sy. J Med Chem. 2007 Sep 20;50(19):4728-45. doi: 10.1021/jm070436q. Epub 2007 Aug 23. J Med Chem. 2007. PMID: 17715908

9

Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1.

Green NJ, Xiang J, Chen J, Chen L, Davies AM, Erbe D, Tam S, Tobin JF. Green NJ, et al. Among authors: tam s. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013. doi: 10.1016/s0968-0896(03)00183-4. Bioorg Med Chem. 2003. PMID: 12788368

10

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

Hu Y, Green N, Gavrin LK, Janz K, Kaila N, Li HQ, Thomason JR, Cuozzo JW, Hall JP, Hsu S, Nickerson-Nutter C, Telliez JB, Lin LL, Tam S. Hu Y, et al. Among authors: tam s. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6067-72. doi: 10.1016/j.bmcl.2006.08.102. Epub 2006 Sep 14. Bioorg Med Chem Lett. 2006. PMID: 16973359

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