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AVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U. de Haan S, et al. Among authors: van hunnik a. Circulation. 2006 Sep 19;114(12):1234-42. doi: 10.1161/CIRCULATIONAHA.106.630905. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940189
Pacing-induced dyssynchrony during early reperfusion reduces infarct size.
Vanagt WY, Cornelussen RN, Baynham TC, Van Hunnik A, Poulina QP, Babiker F, Spinelli J, Delhaas T, Prinzen FW. Vanagt WY, et al. Among authors: van hunnik a. J Am Coll Cardiol. 2007 May 1;49(17):1813-9. doi: 10.1016/j.jacc.2007.01.070. Epub 2007 Apr 16. J Am Coll Cardiol. 2007. PMID: 17466233 Free article.
Myocardial infarction does not preclude electrical and hemodynamic benefits of cardiac resynchronization therapy in dyssynchronous canine hearts.
Rademakers LM, van Kerckhoven R, van Deursen CJ, Strik M, van Hunnik A, Kuiper M, Lampert A, Klersy C, Leyva F, Auricchio A, Maessen JG, Prinzen FW. Rademakers LM, et al. Among authors: van hunnik a, van kerckhoven r, van deursen cj. Circ Arrhythm Electrophysiol. 2010 Aug;3(4):361-8. doi: 10.1161/CIRCEP.109.931865. Epub 2010 May 21. Circ Arrhythm Electrophysiol. 2010. PMID: 20495014
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