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Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2302-5. doi: 10.1016/j.bmcl.2006.01.016. Epub 2006 Feb 3.
Bioorg Med Chem Lett. 2006.
PMID: 16458508
Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.
Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph IB, Rodriguez LE, Maguire MP, Patane MA, Claiborne CF.
Vos TJ, et al. Among authors: drabic sv.
J Med Chem. 2004 Mar 25;47(7):1602-4. doi: 10.1021/jm034244g.
J Med Chem. 2004.
PMID: 15027849
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Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).
Marsilje TH, Roses JB, Calderwood EF, Stroud SG, Forsyth NE, Blackburn C, Yowe DL, Miao W, Drabic SV, Bohane MD, Daniels JS, Li P, Wu L, Patane MA, Claiborne CF.
Marsilje TH, et al. Among authors: drabic sv.
Bioorg Med Chem Lett. 2004 Jul 16;14(14):3721-5. doi: 10.1016/j.bmcl.2004.05.003.
Bioorg Med Chem Lett. 2004.
PMID: 15203150
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