Zhou H - Search Results

1

Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.

Klutchko SR, Zhou H, Winters RT, Tran TP, Bridges AJ, Althaus IW, Amato DM, Elliott WL, Ellis PA, Meade MA, Roberts BJ, Fry DW, Gonzales AJ, Harvey PJ, Nelson JM, Sherwood V, Han HK, Pace G, Smaill JB, Denny WA, Showalter HD. Klutchko SR, et al. Among authors: zhou h. J Med Chem. 2006 Feb 23;49(4):1475-85. doi: 10.1021/jm050936o. J Med Chem. 2006. PMID: 16480284

2

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

Toogood PL, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, Zhou H, Keller PR, McNamara DJ, Sherry D, Zhu T, Brodfuehrer J, Choi C, Barvian MR, Fry DW. Toogood PL, et al. Among authors: zhou h. J Med Chem. 2005 Apr 7;48(7):2388-406. doi: 10.1021/jm049354h. J Med Chem. 2005. PMID: 15801831

3

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

Bridges AJ, Zhou H, Cody DR, Rewcastle GW, McMichael A, Showalter HD, Fry DW, Kraker AJ, Denny WA. Bridges AJ, et al. Among authors: zhou h. J Med Chem. 1996 Jan 5;39(1):267-76. doi: 10.1021/jm9503613. J Med Chem. 1996. PMID: 8568816

4

Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

Rewcastle GW, Palmer BD, Thompson AM, Bridges AJ, Cody DR, Zhou H, Fry DW, McMichael A, Denny WA. Rewcastle GW, et al. Among authors: zhou h. J Med Chem. 1996 Apr 26;39(9):1823-35. doi: 10.1021/jm9508651. J Med Chem. 1996. PMID: 8627606

5

Enantioselective inhibition of the epidermal growth factor receptor tyrosine kinase by 4-(alpha-phenethylamino)quinazolines.

Bridges AJ, Cody DR, Zhou H, McMichael A, Fry DW. Bridges AJ, et al. Among authors: zhou h. Bioorg Med Chem. 1995 Dec;3(12):1651-6. doi: 10.1016/0968-0896(95)00149-2. Bioorg Med Chem. 1995. PMID: 8770389

6

Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

Smaill JB, Palmer BD, Rewcastle GW, Denny WA, McNamara DJ, Dobrusin EM, Bridges AJ, Zhou H, Showalter HD, Winters RT, Leopold WR, Fry DW, Nelson JM, Slintak V, Elliot WL, Roberts BJ, Vincent PW, Patmore SJ. Smaill JB, et al. Among authors: zhou h. J Med Chem. 1999 May 20;42(10):1803-15. doi: 10.1021/jm9806603. J Med Chem. 1999. PMID: 10346932

7

Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]ĭndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase.

Showalter HD, Bridges AJ, Zhou H, Sercel AD, McMichael A, Fry DW. Showalter HD, et al. Among authors: zhou h. J Med Chem. 1999 Dec 30;42(26):5464-74. doi: 10.1021/jm9903949. J Med Chem. 1999. PMID: 10639288

8

Anticancer efficacy of the irreversible EGFr tyrosine kinase inhibitor PD 0169414 against human tumor xenografts.

Vincent PW, Bridges AJ, Dykes DJ, Fry DW, Leopold WR, Patmore SJ, Roberts BJ, Rose S, Sherwood V, Zhou H, Elliott WL. Vincent PW, et al. Among authors: zhou h. Cancer Chemother Pharmacol. 2000;45(3):231-8. doi: 10.1007/s002800050034. Cancer Chemother Pharmacol. 2000. PMID: 10663641

9

Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.

Smaill JB, Showalter HD, Zhou H, Bridges AJ, McNamara DJ, Fry DW, Nelson JM, Sherwood V, Vincent PW, Roberts BJ, Elliott WL, Denny WA. Smaill JB, et al. Among authors: zhou h. J Med Chem. 2001 Feb 1;44(3):429-40. doi: 10.1021/jm000372i. J Med Chem. 2001. PMID: 11462982

10

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

Rewcastle GW, Denny WA, Bridges AJ, Zhou H, Cody DR, McMichael A, Fry DW. Rewcastle GW, et al. Among authors: zhou h. J Med Chem. 1995 Sep 1;38(18):3482-7. doi: 10.1021/jm00018a008. J Med Chem. 1995. PMID: 7658435

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