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Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A. Barter ZE, et al. Among authors: boobis ar. Curr Drug Metab. 2007 Jan;8(1):33-45. doi: 10.2174/138920007779315053. Curr Drug Metab. 2007. PMID: 17266522 Review.
An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.
Andersson TB, Sjöberg H, Hoffmann KJ, Boobis AR, Watts P, Edwards RJ, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Goldfarb PS, Lewis DF, Corcos L, Guillouzo A, Taavitsainen P, Pelkonen O. Andersson TB, et al. Among authors: boobis ar. Drug Metab Dispos. 2001 May;29(5):712-20. Drug Metab Dispos. 2001. PMID: 11302938
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
Salonen JS, Nyman L, Boobis AR, Edwards RJ, Watts P, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF, Taavitsainen P, Pelkonen O. Salonen JS, et al. Among authors: boobis ar. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093. Drug Metab Dispos. 2003. PMID: 12920164
Dissecting the function of cytochrome P450.
Boobis AR, Edwards RJ, Adams DA, Davies DS. Boobis AR, et al. Br J Clin Pharmacol. 1996 Jul;42(1):81-9. doi: 10.1046/j.1365-2125.1996.37912.x. Br J Clin Pharmacol. 1996. PMID: 8807148 Free PMC article. Review.
354 results