Griffith DC - Search Results

1

Pharmacodynamics of levofloxacin against Pseudomonas aeruginosa with reduced susceptibility due to different efflux pumps: do elevated MICs always predict reduced in vivo efficacy?

Griffith DC, Corcoran E, Lofland D, Lee A, Cho D, Lomovskaya O, Dudley MN. Griffith DC, et al. Antimicrob Agents Chemother. 2006 May;50(5):1628-32. doi: 10.1128/AAC.50.5.1628-1632.2006. Antimicrob Agents Chemother. 2006. PMID: 16641428 Free PMC article.

2

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

Renau TE, Léger R, Flamme EM, Sangalang J, She MW, Yen R, Gannon CL, Griffith D, Chamberland S, Lomovskaya O, Hecker SJ, Lee VJ, Ohta T, Nakayama K. Renau TE, et al. J Med Chem. 1999 Dec 2;42(24):4928-31. doi: 10.1021/jm9904598. J Med Chem. 1999. PMID: 10585202 No abstract available.

3

SAR studies of anti-MRSA non-zwitterionic 3-heteroarylthiocephems.

Glinka TW, Cho A, Zhang ZJ, Ludwikow M, Griffith D, Huie K, Hecker SJ, Dudley MN, Lee VJ, Chamberland S. Glinka TW, et al. J Antibiot (Tokyo). 2000 Oct;53(10):1045-52. doi: 10.7164/antibiotics.53.1045. J Antibiot (Tokyo). 2000. PMID: 11132949 Free article.

4

In vivo antibacterial activity of RWJ-54428, a new cephalosporin with activity against gram-positive bacteria.

Griffith DC, Harford L, Williams R, Lee VJ, Dudley MN. Griffith DC, et al. Antimicrob Agents Chemother. 2003 Jan;47(1):43-7. doi: 10.1128/AAC.47.1.43-47.2003. Antimicrob Agents Chemother. 2003. PMID: 12499167 Free PMC article.

5

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

Glinka T, Huie K, Cho A, Ludwikow M, Blais J, Griffith D, Hecker S, Dudley M. Glinka T, et al. Bioorg Med Chem. 2003 Feb 20;11(4):591-600. doi: 10.1016/s0968-0896(02)00431-5. Bioorg Med Chem. 2003. PMID: 12538024

6

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

Renau TE, Léger R, Filonova L, Flamme EM, Wang M, Yen R, Madsen D, Griffith D, Chamberland S, Dudley MN, Lee VJ, Lomovskaya O, Watkins WJ, Ohta T, Nakayama K, Ishida Y. Renau TE, et al. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2755-8. doi: 10.1016/s0960-894x(03)00556-0. Bioorg Med Chem Lett. 2003. PMID: 12873508

7

The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors.

Watkins WJ, Landaverry Y, Léger R, Litman R, Renau TE, Williams N, Yen R, Zhang JZ, Chamberland S, Madsen D, Griffith D, Tembe V, Huie K, Dudley MN. Watkins WJ, et al. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4241-4. doi: 10.1016/j.bmcl.2003.07.030. Bioorg Med Chem Lett. 2003. PMID: 14623009

8

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.

Watkins WJ, Chong L, Cho A, Hilgenkamp R, Ludwikow M, Garizi N, Iqbal N, Barnard J, Singh R, Madsen D, Lolans K, Lomovskaya O, Oza U, Kumaraswamy P, Blecken A, Bai S, Loury DJ, Griffith DC, Dudley MN. Watkins WJ, et al. Among authors: griffith dc. Bioorg Med Chem Lett. 2007 May 15;17(10):2802-6. doi: 10.1016/j.bmcl.2007.02.047. Epub 2007 Feb 27. Bioorg Med Chem Lett. 2007. PMID: 17350259

9

Pharmacodynamics of RWJ-54428 against Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis in a neutropenic mouse thigh infection model.

Griffith DC, Rodriguez D, Corcoran E, Dudley MN. Griffith DC, et al. Antimicrob Agents Chemother. 2008 Jan;52(1):244-7. doi: 10.1128/AAC.00776-07. Epub 2007 Oct 22. Antimicrob Agents Chemother. 2008. PMID: 17954697 Free PMC article.

10

Aerosol antibiotics: considerations in pharmacological and clinical evaluation.

Dudley MN, Loutit J, Griffith DC. Dudley MN, et al. Among authors: griffith dc. Curr Opin Biotechnol. 2008 Dec;19(6):637-43. doi: 10.1016/j.copbio.2008.11.002. Epub 2008 Nov 25. Curr Opin Biotechnol. 2008. PMID: 19036576 Review.

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