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The FIP1L1-PDGFRA T674I mutation can be inhibited by the tyrosine kinase inhibitor AMN107 (nilotinib).
Blood. 2006 Jun 15;107(12):4970-1; author reply 4972. doi: 10.1182/blood-2006-01-0285.
Blood. 2006.
PMID: 16754777
Free article.
No abstract available.
The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.
von Bubnoff N, Gorantla SP, Engh RA, Oliveira TM, Thöne S, Aberg E, Peschel C, Duyster J.
von Bubnoff N, et al. Among authors: thone s.
Oncogene. 2011 Feb 24;30(8):933-43. doi: 10.1038/onc.2010.476. Epub 2010 Oct 25.
Oncogene. 2011.
PMID: 20972453
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[The SOFA score in evaluating septic illnesses. Correlations with the MOD and APACHE II score].
Hantke M, Holzer K, Thöne S, Schmandra T, Hanisch E.
Hantke M, et al. Among authors: thone s.
Chirurg. 2000 Oct;71(10):1270-6. doi: 10.1007/s001040051214.
Chirurg. 2000.
PMID: 11077590
German.
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