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A nonreplicating adenoviral vector that contains the wild-type p53 transgene combined with chemotherapy for primary breast cancer: safety, efficacy, and biologic activity of a novel gene-therapy approach.
Cristofanilli M, Krishnamurthy S, Guerra L, Broglio K, Arun B, Booser DJ, Menander K, Van Wart Hood J, Valero V, Hortobagyi GN. Cristofanilli M, et al. Among authors: van wart hood j. Cancer. 2006 Sep 1;107(5):935-44. doi: 10.1002/cncr.22080. Cancer. 2006. PMID: 16874816 Free article. Clinical Trial.
Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer.
Tolcher AW, Hao D, de Bono J, Miller A, Patnaik A, Hammond LA, Smetzer L, Van Wart Hood J, Merritt J, Rowinsky EK, Takimoto C, Von Hoff D, Eckhardt SG. Tolcher AW, et al. Among authors: van wart hood j. J Clin Oncol. 2006 May 1;24(13):2052-8. doi: 10.1200/JCO.2005.03.6756. J Clin Oncol. 2006. PMID: 16648505 Clinical Trial.
Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.
Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S. Tong AW, et al. Among authors: van wart hood j. Mol Ther. 2005 Jan;11(1):160-72. doi: 10.1016/j.ymthe.2004.09.021. Mol Ther. 2005. PMID: 15585417 Free article. Clinical Trial.