Azzi A - Search Results

1

Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase.

Qiu W, Zhou M, Mazumdar M, Azzi A, Ghanmi D, Luu-The V, Labrie F, Lin SX. Qiu W, et al. Among authors: azzi a. J Biol Chem. 2007 Mar 16;282(11):8368-79. doi: 10.1074/jbc.M606784200. Epub 2006 Dec 13. J Biol Chem. 2007. PMID: 17166832 Free article.

2

Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis.

Qiu W, Zhu DW, Azzi A, Campbell RL, Qi H, Poirier D, Lin SX. Qiu W, et al. Among authors: azzi a. J Steroid Biochem Mol Biol. 1999 Mar;68(5-6):239-44. doi: 10.1016/s0960-0760(99)00036-9. J Steroid Biochem Mol Biol. 1999. PMID: 10416839

Mol. Biol. 234:242; Ghosh et al., 1995, Structure 3:503; Azzi et al., 1996, Nature Struct. Biol. 3:665). The determination of the non-reactive ternary complex structure, which could mimic the transition state, constitutes a further critical step toward the rational …

Mol. Biol. 234:242; Ghosh et al., 1995, Structure 3:503; Azzi et al., 1996, Nature Struct. Biol. 3:665). The determination of the non …

3

Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5.

Lin SX, Shi R, Qiu W, Azzi A, Zhu DW, Dabbagh HA, Zhou M. Lin SX, et al. Among authors: azzi a. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):38-46. doi: 10.1016/j.mce.2005.11.035. Epub 2006 Feb 15. Mol Cell Endocrinol. 2006. PMID: 16480815 Review.

4

Human SARS-coronavirus RNA-dependent RNA polymerase: activity determinants and nucleoside analogue inhibitors.

Azzi A, Lin SX. Azzi A, et al. Proteins. 2004 Oct 1;57(1):12-4. doi: 10.1002/prot.20194. Proteins. 2004. PMID: 15326590 Free PMC article. No abstract available.

5

Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase.

Poirier D, Chang HJ, Azzi A, Boivin RP, Lin SX. Poirier D, et al. Among authors: azzi a. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):236-8. doi: 10.1016/j.mce.2005.10.017. Epub 2005 Dec 7. Mol Cell Endocrinol. 2006. PMID: 16337735

6

Structure function analysis of west nile virus RNA dependent RNA polymerase: molecular model and implications for drug design.

Azzi A, Lin SX. Azzi A, et al. Med Chem. 2007 Sep;3(5):455-9. doi: 10.2174/157340607781745438. Med Chem. 2007. PMID: 17897070

7

Preparation of the apoenzyme and holoenzyme forms of human 17 beta-hydroxysteroid dehydrogenase.

Jin JZ, Azzi A, Wang JY, Lin SX. Jin JZ, et al. Among authors: azzi a. J Chromatogr. 1993 Apr 21;614(1):159-63. doi: 10.1016/0378-4347(93)80236-w. J Chromatogr. 1993. PMID: 8496277

8

Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.

Lin SX, Zhu DW, Azzi A, Campbell RL, Breton R, Labrie F, Ghosh D, Pletnev V, Duax WL, Pangborn W. Lin SX, et al. Among authors: azzi a. J Endocrinol. 1996 Sep;150 Suppl:S13-20. J Endocrinol. 1996. PMID: 8943782

9

Crystallization and preliminary crystallographic analysis of the snake muscle fructose 1,6-bisphosphatase.

Zhu DW, Xu GJ, Rehse PH, Azzi A, Zhao FK, Lin SX. Zhu DW, et al. Among authors: azzi a. Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1342-4. doi: 10.1107/s0907444999004977. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10393302

10

3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.

Lin SX, Han Q, Azzi A, Zhu DW, Gangloff A, Campbell RL. Lin SX, et al. Among authors: azzi a. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):425-9. doi: 10.1016/s0960-0760(99)00062-x. J Steroid Biochem Mol Biol. 1999. PMID: 10419021 Review.

The substrate specificity is due to a combination of hydrogen bonding and hydrophobic interactions between the steroid and the enzyme binding pocket. ...In the case of the C19 androgen, several residues within the enzyme active site make some small adjustments to accommoda …

The substrate specificity is due to a combination of hydrogen bonding and hydrophobic interactions between the steroid and the enzyme …

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