Gilbert IH - Search Results

1

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates.

Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN. Sundaramoorthy R, et al. Among authors: gilbert ih. FEBS J. 2007 Jan;274(1):275-86. doi: 10.1111/j.1742-4658.2006.05585.x. FEBS J. 2007. PMID: 17222187 Free PMC article.

2

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: gilbert ih. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

3

Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.

Bertelli M, El-Bastawissy E, Knaggs MH, Barrett MP, Hanau S, Gilbert IH. Bertelli M, et al. Among authors: gilbert ih. J Comput Aided Mol Des. 2001 May;15(5):465-75. doi: 10.1023/a:1011196508214. J Comput Aided Mol Des. 2001. PMID: 11394739

4

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

Klenke B, Stewart M, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: gilbert ih. J Med Chem. 2001 Oct 11;44(21):3440-52. doi: 10.1021/jm010854+. J Med Chem. 2001. PMID: 11585449

5

Perspectives for new drugs against trypanosomiasis and leishmaniasis.

Barrett MP, Gilbert IH. Barrett MP, et al. Among authors: gilbert ih. Curr Top Med Chem. 2002 May;2(5):471-82. doi: 10.2174/1568026024607427. Curr Top Med Chem. 2002. PMID: 11966468 Review.

6

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis.

Dardonville C, Rinaldi E, Hanau S, Barrett MP, Brun R, Gilbert IH. Dardonville C, et al. Among authors: gilbert ih. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. doi: 10.1016/s0968-0896(03)00191-3. Bioorg Med Chem. 2003. PMID: 12818683

7

Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.

Klenke B, Barrett MP, Brun R, Gilbert IH. Klenke B, et al. Among authors: gilbert ih. J Antimicrob Chemother. 2003 Aug;52(2):290-3. doi: 10.1093/jac/dkg307. Epub 2003 Jul 1. J Antimicrob Chemother. 2003. PMID: 12837742

8

Trypanocidal activity of melamine-based nitroheterocycles.

Stewart ML, Bueno GJ, Baliani A, Klenke B, Brun R, Brock JM, Gilbert IH, Barrett MP. Stewart ML, et al. Among authors: gilbert ih. Antimicrob Agents Chemother. 2004 May;48(5):1733-8. doi: 10.1128/AAC.48.5.1733-1738.2004. Antimicrob Agents Chemother. 2004. PMID: 15105128 Free PMC article.

9

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues.

Dardonville C, Rinaldi E, Barrett MP, Brun R, Gilbert IH, Hanau S. Dardonville C, et al. Among authors: gilbert ih. J Med Chem. 2004 Jun 17;47(13):3427-37. doi: 10.1021/jm031066i. J Med Chem. 2004. PMID: 15189039

10

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes.

Hanau S, Rinaldi E, Dallocchio F, Gilbert IH, Dardonville C, Adams MJ, Gover S, Barrett MP. Hanau S, et al. Among authors: gilbert ih. Curr Med Chem. 2004 Oct;11(19):2639-50. doi: 10.2174/0929867043364441. Curr Med Chem. 2004. PMID: 15544466 Review.

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