Sacchettini JC - Search Results

1

Mechanism of thioamide drug action against tuberculosis and leprosy.

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC. Wang F, et al. Among authors: sacchettini jc. J Exp Med. 2007 Jan 22;204(1):73-8. doi: 10.1084/jem.20062100. Epub 2007 Jan 16. J Exp Med. 2007. PMID: 17227913 Free PMC article.

2

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

Quémard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. Quémard A, et al. Among authors: sacchettini jc. Biochemistry. 1995 Jul 4;34(26):8235-41. doi: 10.1021/bi00026a004. Biochemistry. 1995. PMID: 7599116

3

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

Dessen A, Quémard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC. Dessen A, et al. Among authors: sacchettini jc. Science. 1995 Mar 17;267(5204):1638-41. doi: 10.1126/science.7886450. Science. 1995. PMID: 7886450

4

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. Science. 1998 Jan 2;279(5347):98-102. doi: 10.1126/science.279.5347.98. Science. 1998. PMID: 9417034

5

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.

Klabunde T, Sharma S, Telenti A, Jacobs WR Jr, Sacchettini JC. Klabunde T, et al. Among authors: sacchettini jc. Nat Struct Biol. 1998 Jan;5(1):31-6. doi: 10.1038/nsb0198-31. Nat Struct Biol. 1998. PMID: 9437427

6

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. Banerjee A, et al. Among authors: sacchettini jc. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2697-2704. doi: 10.1099/00221287-144-10-2697. Microbiology (Reading). 1998. PMID: 9802011 Free article.

7

Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

Sharma V, Grubmeyer C, Sacchettini JC. Sharma V, et al. Among authors: sacchettini jc. Structure. 1998 Dec 15;6(12):1587-99. doi: 10.1016/s0969-2126(98)00156-7. Structure. 1998. PMID: 9862811 Free article.

8

Mechanisms for isoniazid action and resistance.

Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR Jr. Miesel L, et al. Among authors: sacchettini jc. Novartis Found Symp. 1998;217:209-20; discussion 220-1. doi: 10.1002/0470846526.ch15. Novartis Found Symp. 1998. PMID: 9949810 Review.

9

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.

Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC. Ronning DR, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Feb;7(2):141-6. doi: 10.1038/72413. Nat Struct Biol. 2000. PMID: 10655617

10

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.

Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: sacchettini jc. J Bacteriol. 2000 Jul;182(14):4059-67. doi: 10.1128/JB.182.14.4059-4067.2000. J Bacteriol. 2000. PMID: 10869086 Free PMC article.

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