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Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid.
Sakaki T, Sawada N, Nonaka Y, Ohyama Y, Inouye K. Sakaki T, et al. Eur J Biochem. 1999 May;262(1):43-8. doi: 10.1046/j.1432-1327.1999.00375.x. Eur J Biochem. 1999. PMID: 10231362 Free article.
Previously we expressed rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) cDNA in Escherichia coli JM109 and showed that CYP24 catalyses three-step monooxygenation towards 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3 [Akiyoshi-Shibata, M., Sakaki, T., Ohyama …
Previously we expressed rat 25-hydroxyvitamin D3 24-hydroxylase (CYP24) cDNA in Escherichia coli JM109 and showed that CYP24 catalyses three …
No enzyme activity of 25-hydroxyvitamin D3 1alpha-hydroxylase gene product in pseudovitamin D deficiency rickets, including that with mild clinical manifestation.
Kitanaka S, Murayama A, Sakaki T, Inouye K, Seino Y, Fukumoto S, Shima M, Yukizane S, Takayanagi M, Niimi H, Takeyama K, Kato S. Kitanaka S, et al. Among authors: sakaki t. J Clin Endocrinol Metab. 1999 Nov;84(11):4111-7. doi: 10.1210/jcem.84.11.6131. J Clin Endocrinol Metab. 1999. PMID: 10566658
Metabolism of vitamin D(3) by human CYP27A1.
Sawada N, Sakaki T, Ohta M, Inouye K. Sawada N, et al. Among authors: sakaki t. Biochem Biophys Res Commun. 2000 Jul 14;273(3):977-84. doi: 10.1006/bbrc.2000.3050. Biochem Biophys Res Commun. 2000. PMID: 10891358
Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.
Sakaki T, Sawada N, Komai K, Shiozawa S, Yamada S, Yamamoto K, Ohyama Y, Inouye K. Sakaki T, et al. Eur J Biochem. 2000 Oct;267(20):6158-65. doi: 10.1046/j.1432-1327.2000.01680.x. Eur J Biochem. 2000. PMID: 11012668 Free article.
Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25(OH)2D3, whereas rat CYP24 showed almost no C-23 hydroxylation pathway [Sakaki, T. Sawada, N. Nonaka, Y. Ohyama, Y. & Inou …
Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25 …
705 results