Brown ED - Search Results

1

High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones.

Tropak MB, Blanchard JE, Withers SG, Brown ED, Mahuran D. Tropak MB, et al. Among authors: brown ed. Chem Biol. 2007 Feb;14(2):153-64. doi: 10.1016/j.chembiol.2006.12.006. Chem Biol. 2007. PMID: 17317569 Free PMC article.

2

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.

Blanchard JE, Elowe NH, Huitema C, Fortin PD, Cechetto JD, Eltis LD, Brown ED. Blanchard JE, et al. Among authors: brown ed. Chem Biol. 2004 Oct;11(10):1445-53. doi: 10.1016/j.chembiol.2004.08.011. Chem Biol. 2004. PMID: 15489171 Free PMC article.

3

Experimental screening of dihydrofolate reductase yields a "test set" of 50,000 small molecules for a computational data-mining and docking competition.

Elowe NH, Blanchard JE, Cechetto JD, Brown ED. Elowe NH, et al. Among authors: brown ed. J Biomol Screen. 2005 Oct;10(7):653-7. doi: 10.1177/1087057105281173. Epub 2005 Sep 16. J Biomol Screen. 2005. PMID: 16170050

4

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD. Ejim LJ, et al. Among authors: brown ed. J Med Chem. 2007 Feb 22;50(4):755-64. doi: 10.1021/jm061132r. J Med Chem. 2007. PMID: 17300162

5

Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.

Tropak MB, Kornhaber GJ, Rigat BA, Maegawa GH, Buttner JD, Blanchard JE, Murphy C, Tuske SJ, Coales SJ, Hamuro Y, Brown ED, Mahuran DJ. Tropak MB, et al. Among authors: brown ed. Chembiochem. 2008 Nov 3;9(16):2650-62. doi: 10.1002/cbic.200800304. Chembiochem. 2008. PMID: 18972510 Free PMC article.

6

High-throughput screening of model bacteria.

Zlitni S, Blanchard JE, Brown ED. Zlitni S, et al. Among authors: brown ed. Methods Mol Biol. 2009;486:13-27. doi: 10.1007/978-1-60327-545-3_2. Methods Mol Biol. 2009. PMID: 19347613

7

High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU.

Pereira MP, Blanchard JE, Murphy C, Roderick SL, Brown ED. Pereira MP, et al. Among authors: brown ed. Antimicrob Agents Chemother. 2009 Jun;53(6):2306-11. doi: 10.1128/AAC.01572-08. Epub 2009 Apr 6. Antimicrob Agents Chemother. 2009. PMID: 19349513 Free PMC article.

8

A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers.

Diallo JS, Le Boeuf F, Lai F, Cox J, Vaha-Koskela M, Abdelbary H, MacTavish H, Waite K, Falls T, Wang J, Brown R, Blanchard JE, Brown ED, Kirn DH, Hiscott J, Atkins H, Lichty BD, Bell JC. Diallo JS, et al. Among authors: brown r, brown ed. Mol Ther. 2010 Jun;18(6):1123-9. doi: 10.1038/mt.2010.67. Epub 2010 Apr 13. Mol Ther. 2010. PMID: 20389287 Free PMC article.

9

A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis.

Bharat A, Blanchard JE, Brown ED. Bharat A, et al. Among authors: brown ed. J Biomol Screen. 2013 Aug;18(7):830-6. doi: 10.1177/1087057113486001. Epub 2013 Apr 19. J Biomol Screen. 2013. PMID: 23606650 Free PMC article.

10

Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase.

Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC. Sobhanifar S, et al. Among authors: brown ed. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E576-85. doi: 10.1073/pnas.1418084112. Epub 2015 Jan 26. Proc Natl Acad Sci U S A. 2015. PMID: 25624472 Free PMC article.

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