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Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ. Zhang F, et al. Among authors: thornhill si. Blood. 2007 Sep 1;110(5):1448-57. doi: 10.1182/blood-2006-12-060814. Epub 2007 Apr 24. Blood. 2007. PMID: 17456723 Free PMC article.
Gene therapy of inherited immunodeficiencies.
Santilli G, Thornhill SI, Kinnon C, Thrasher AJ. Santilli G, et al. Among authors: thornhill si. Expert Opin Biol Ther. 2008 Apr;8(4):397-407. doi: 10.1517/14712598.8.4.397. Expert Opin Biol Ther. 2008. PMID: 18352845 Review.
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H, Brugman MH, Pike-Overzet K, Chatters SJ, de Ridder D, Gilmour KC, Adams S, Thornhill SI, Parsley KL, Staal FJ, Gale RE, Linch DC, Bayford J, Brown L, Quaye M, Kinnon C, Ancliff P, Webb DK, Schmidt M, von Kalle C, Gaspar HB, Thrasher AJ. Howe SJ, et al. Among authors: thornhill si. J Clin Invest. 2008 Sep;118(9):3143-50. doi: 10.1172/JCI35798. J Clin Invest. 2008. PMID: 18688286 Free PMC article. Clinical Trial.
Correction of SCID-X1 using an enhancerless Vav promoter.
Almarza E, Zhang F, Santilli G, Blundell MP, Howe SJ, Thornhill SI, Bueren JA, Thrasher AJ. Almarza E, et al. Among authors: thornhill si. Hum Gene Ther. 2011 Mar;22(3):263-70. doi: 10.1089/hum.2010.119. Epub 2011 Feb 7. Hum Gene Ther. 2011. PMID: 20887212
RNA sensing by conventional dendritic cells is central to the development of lupus nephritis.
Celhar T, Hopkins R, Thornhill SI, De Magalhaes R, Hwang SH, Lee HY, Yasuga H, Jones LA, Casco J, Lee B, Thamboo TP, Zhou XJ, Poidinger M, Connolly JE, Wakeland EK, Fairhurst AM. Celhar T, et al. Among authors: thornhill si. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6195-204. doi: 10.1073/pnas.1507052112. Epub 2015 Oct 28. Proc Natl Acad Sci U S A. 2015. PMID: 26512111 Free PMC article.
Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice.
Celhar T, Yasuga H, Lee HY, Zharkova O, Tripathi S, Thornhill SI, Lu HK, Au B, Lim LHK, Thamboo TP, Akira S, Wakeland EK, Connolly JE, Fairhurst AM. Celhar T, et al. Among authors: thornhill si. Arthritis Rheumatol. 2018 Oct;70(10):1597-1609. doi: 10.1002/art.40535. Arthritis Rheumatol. 2018. PMID: 29687651 Free PMC article.
TLR7 and TLR9 ligands regulate antigen presentation by macrophages.
Celhar T, Pereira-Lopes S, Thornhill SI, Lee HY, Dhillon MK, Poidinger M, Connolly JE, Lim LH, Biswas SK, Fairhurst AM. Celhar T, et al. Among authors: thornhill si. Int Immunol. 2016 May;28(5):223-32. doi: 10.1093/intimm/dxv066. Epub 2015 Nov 13. Int Immunol. 2016. PMID: 26567289 Free PMC article.
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