Biernat J - Search Results

1

Structural principles of tau and the paired helical filaments of Alzheimer's disease.

Mandelkow E, von Bergen M, Biernat J, Mandelkow EM. Mandelkow E, et al. Among authors: biernat j. Brain Pathol. 2007 Jan;17(1):83-90. doi: 10.1111/j.1750-3639.2007.00053.x. Brain Pathol. 2007. PMID: 17493042 Free PMC article. Review.

2

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells.

Pickhardt M, Gazova Z, von Bergen M, Khlistunova I, Wang Y, Hascher A, Mandelkow EM, Biernat J, Mandelkow E. Pickhardt M, et al. Among authors: biernat j. J Biol Chem. 2005 Feb 4;280(5):3628-35. doi: 10.1074/jbc.M410984200. Epub 2004 Nov 2. J Biol Chem. 2005. PMID: 15525637 Free article.

3

Tau aggregation is driven by a transition from random coil to beta sheet structure.

von Bergen M, Barghorn S, Biernat J, Mandelkow EM, Mandelkow E. von Bergen M, et al. Among authors: biernat j. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):158-66. doi: 10.1016/j.bbadis.2004.09.010. Epub 2004 Nov 12. Biochim Biophys Acta. 2005. PMID: 15615635 Free article. Review.

4

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions.

Mukrasch MD, Biernat J, von Bergen M, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: biernat j. J Biol Chem. 2005 Jul 1;280(26):24978-86. doi: 10.1074/jbc.M501565200. Epub 2005 Apr 26. J Biol Chem. 2005. PMID: 15855160 Free article.

5

Screening for inhibitors of tau polymerization.

Pickhardt M, von Bergen M, Gazova Z, Hascher A, Biernat J, Mandelkow EM, Mandelkow E. Pickhardt M, et al. Among authors: biernat j. Curr Alzheimer Res. 2005 Apr;2(2):219-26. doi: 10.2174/1567205053585891. Curr Alzheimer Res. 2005. PMID: 15974921

6

Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.

Barghorn S, Biernat J, Mandelkow E. Barghorn S, et al. Among authors: biernat j. Methods Mol Biol. 2005;299:35-51. doi: 10.1385/1-59259-874-9:035. Methods Mol Biol. 2005. PMID: 15980594

7

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.

Khlistunova I, Biernat J, Wang Y, Pickhardt M, von Bergen M, Gazova Z, Mandelkow E, Mandelkow EM. Khlistunova I, et al. Among authors: biernat j. J Biol Chem. 2006 Jan 13;281(2):1205-14. doi: 10.1074/jbc.M507753200. Epub 2005 Oct 24. J Biol Chem. 2006. PMID: 16246844 Free article.

8

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis.

von Bergen M, Barghorn S, Müller SA, Pickhardt M, Biernat J, Mandelkow EM, Davies P, Aebi U, Mandelkow E. von Bergen M, et al. Among authors: biernat j. Biochemistry. 2006 May 23;45(20):6446-57. doi: 10.1021/bi052530j. Biochemistry. 2006. PMID: 16700555

9

Structural and microtubule binding properties of tau mutants of frontotemporal dementias.

Fischer D, Mukrasch MD, von Bergen M, Klos-Witkowska A, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. Fischer D, et al. Among authors: biernat j. Biochemistry. 2007 Mar 13;46(10):2574-82. doi: 10.1021/bi061318s. Epub 2007 Feb 13. Biochemistry. 2007. PMID: 17297915

10

The "jaws" of the tau-microtubule interaction.

Mukrasch MD, von Bergen M, Biernat J, Fischer D, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: biernat j. J Biol Chem. 2007 Apr 20;282(16):12230-9. doi: 10.1074/jbc.M607159200. Epub 2007 Feb 15. J Biol Chem. 2007. PMID: 17307736 Free article.

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