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Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.
Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, De Mello FG, Inestrosa NC. Alvarez A, et al. Among authors: inestrosa nc. J Neurosci. 1998 May 1;18(9):3213-23. doi: 10.1523/JNEUROSCI.18-09-03213.1998. J Neurosci. 1998. PMID: 9547230 Free PMC article.
Wnt signaling function in Alzheimer's disease.
De Ferrari GV, Inestrosa NC. De Ferrari GV, et al. Among authors: inestrosa nc. Brain Res Brain Res Rev. 2000 Aug;33(1):1-12. doi: 10.1016/s0165-0173(00)00021-7. Brain Res Brain Res Rev. 2000. PMID: 10967351 Review.
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
Opazo C, Huang X, Cherny RA, Moir RD, Roher AE, White AR, Cappai R, Masters CL, Tanzi RE, Inestrosa NC, Bush AI. Opazo C, et al. Among authors: inestrosa nc. J Biol Chem. 2002 Oct 25;277(43):40302-8. doi: 10.1074/jbc.M206428200. Epub 2002 Aug 20. J Biol Chem. 2002. PMID: 12192006 Free article.
394 results