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Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: du j. Antimicrob Agents Chemother. 2011 Jun;55(6):2566-75. doi: 10.1128/AAC.00032-11. Epub 2011 Mar 28. Antimicrob Agents Chemother. 2011. PMID: 21444700 Free PMC article.
Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
Furman PA, Murakami E, Niu C, Lam AM, Espiritu C, Bansal S, Bao H, Tolstykh T, Micolochick Steuer H, Keilman M, Zennou V, Bourne N, Veselenak RL, Chang W, Ross BS, Du J, Otto MJ, Sofia MJ. Furman PA, et al. Among authors: du j. Antiviral Res. 2011 Aug;91(2):120-32. doi: 10.1016/j.antiviral.2011.05.003. Epub 2011 May 12. Antiviral Res. 2011. PMID: 21600932 Free PMC article.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Chang W, Du J, Rachakonda S, Ross BS, Convers-Reignier S, Yau WT, Pons JF, Murakami E, Bao H, Steuer HM, Furman PA, Otto MJ, Sofia MJ. Chang W, et al. Among authors: du j. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4539-43. doi: 10.1016/j.bmcl.2010.06.025. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580554
Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938.
Niu C, Tolstykh T, Bao H, Park Y, Babusis D, Lam AM, Bansal S, Du J, Chang W, Reddy PG, Zhang HR, Woolley J, Wang LQ, Chao PB, Ray AS, Otto MJ, Sofia MJ, Furman PA, Murakami E. Niu C, et al. Among authors: du j. Antimicrob Agents Chemother. 2012 Jul;56(7):3767-75. doi: 10.1128/AAC.00530-12. Epub 2012 Apr 23. Antimicrob Agents Chemother. 2012. PMID: 22526308 Free PMC article.
β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Du J, Bao D, Chun BK, Jiang Y, Reddy PG, Zhang HR, Ross BS, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Otto MJ, Sofia MJ. Du J, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5924-9. doi: 10.1016/j.bmcl.2012.07.066. Epub 2012 Jul 27. Bioorg Med Chem Lett. 2012. PMID: 22892115
Use of 2'-spirocyclic ethers in HCV nucleoside design.
Du J, Chun BK, Mosley RT, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Sofia MJ. Du J, et al. J Med Chem. 2014 Mar 13;57(5):1826-35. doi: 10.1021/jm401224y. Epub 2013 Oct 18. J Med Chem. 2014. PMID: 24079820
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