Wang Y - Search Results

1

Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.

Wang Y, Ji QS, Mulvihill M, Pachter JA. Wang Y, et al. Recent Results Cancer Res. 2007;172:59-76. doi: 10.1007/978-3-540-31209-3_5. Recent Results Cancer Res. 2007. PMID: 17607936 Review. No abstract available.

2

Screening for small molecule inhibitors of insulin-like growth factor receptor (IGF-1R) kinase: comparison of homogeneous time-resolved fluorescence and 33P-ATP plate assay formats.

Wang Y, Malkowski M, Hailey J, Turek-Etienne T, Tripodi T, Pachter JA. Wang Y, et al. J Exp Ther Oncol. 2004 Jul;4(2):111-9. J Exp Ther Oncol. 2004. PMID: 15500006

3

Neutralizing anti-insulin-like growth factor receptor 1 antibodies inhibit receptor function and induce receptor degradation in tumor cells.

Hailey J, Maxwell E, Koukouras K, Bishop WR, Pachter JA, Wang Y. Hailey J, et al. Among authors: wang y. Mol Cancer Ther. 2002 Dec;1(14):1349-53. Mol Cancer Ther. 2002. PMID: 12516969

4

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody.

Wang Y, Hailey J, Williams D, Wang Y, Lipari P, Malkowski M, Wang X, Xie L, Li G, Saha D, Ling WL, Cannon-Carlson S, Greenberg R, Ramos RA, Shields R, Presta L, Brams P, Bishop WR, Pachter JA. Wang Y, et al. Among authors: wang x. Mol Cancer Ther. 2005 Aug;4(8):1214-21. doi: 10.1158/1535-7163.MCT-05-0048. Mol Cancer Ther. 2005. PMID: 16093437

5

A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts.

Wang Y, Lipari P, Wang X, Hailey J, Liang L, Ramos R, Liu M, Pachter JA, Bishop WR, Wang Y. Wang Y, et al. Among authors: wang x. Mol Cancer Ther. 2010 Feb;9(2):410-8. doi: 10.1158/1535-7163.MCT-09-0555. Epub 2010 Feb 2. Mol Cancer Ther. 2010. PMID: 20124453

6

RNA interference targeting of A1 receptor-overexpressing breast carcinoma cells leads to diminished rates of cell proliferation and induction of apoptosis.

Mirza A, Basso A, Black S, Malkowski M, Kwee L, Pachter JA, Lachowicz JE, Wang Y, Liu S. Mirza A, et al. Among authors: wang y. Cancer Biol Ther. 2005 Dec;4(12):1355-60. doi: 10.4161/cbt.4.12.2196. Epub 2005 Dec 21. Cancer Biol Ther. 2005. PMID: 16294023

7

Measurement of the functional affinity constant of a monoclonal antibody for cell surface receptors using kinetic exclusion fluorescence immunoassay.

Xie L, Mark Jones R, Glass TR, Navoa R, Wang Y, Grace MJ. Xie L, et al. Among authors: wang y. J Immunol Methods. 2005 Sep;304(1-2):1-14. doi: 10.1016/j.jim.2005.04.009. J Immunol Methods. 2005. PMID: 16098983

8

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.

Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ. Dwyer MP, et al. Among authors: wang y. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6178-82. doi: 10.1016/j.bmcl.2013.08.110. Epub 2013 Sep 7. Bioorg Med Chem Lett. 2013. PMID: 24091081

9

Improvement of monoclonal antibody production in hybridoma cells by dimethyl sulfoxide.

Ling WL, Deng L, Lepore J, Cutler C, Cannon-Carlson S, Wang Y, Voloch M. Ling WL, et al. Among authors: wang y. Biotechnol Prog. 2003 Jan-Feb;19(1):158-62. doi: 10.1021/bp020068d. Biotechnol Prog. 2003. PMID: 12573019

10

Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.

Li HY, McMillen WT, Heap CR, McCann DJ, Yan L, Campbell RM, Mundla SR, King CH, Dierks EA, Anderson BD, Britt KS, Huss KL, Voss MD, Wang Y, Clawson DK, Yingling JM, Sawyer JS. Li HY, et al. Among authors: wang y. J Med Chem. 2008 Apr 10;51(7):2302-6. doi: 10.1021/jm701199p. Epub 2008 Mar 4. J Med Chem. 2008. PMID: 18314943

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