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Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).
Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC. Lai Y, et al. Among authors: cox sr. J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. doi: 10.1124/jpet.110.170753. Epub 2010 Jun 2. J Pharmacol Exp Ther. 2010. PMID: 20519552 Clinical Trial.
Valdecoxib, a COX-2-specific inhibitor, does not affect cardiac repolarization.
Sarapa N, Britto MR, Cotton B, Cox SR, Francom SF, Jin N, Polasek ED, Sainati SM, Crosby-Sessoms SL, Fleishaker JC. Sarapa N, et al. Among authors: cox sr. J Clin Pharmacol. 2003 Sep;43(9):974-82. doi: 10.1177/0091270003257220. J Clin Pharmacol. 2003. PMID: 12971029 Clinical Trial.
280 results