Gintant GA - Search Results

1

Functional consequences of methionine oxidation of hERG potassium channels.

Su Z, Limberis J, Martin RL, Xu R, Kolbe K, Heinemann SH, Hoshi T, Cox BF, Gintant GA. Su Z, et al. Among authors: gintant ga. Biochem Pharmacol. 2007 Sep 1;74(5):702-11. doi: 10.1016/j.bcp.2007.06.002. Epub 2007 Jun 7. Biochem Pharmacol. 2007. PMID: 17624316 Free PMC article.

2

Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K+ channel.

Su Z, Martin R, Cox BF, Gintant G. Su Z, et al. J Mol Cell Cardiol. 2004 Jan;36(1):151-60. doi: 10.1016/j.yjmcc.2003.10.017. J Mol Cell Cardiol. 2004. PMID: 14734057

3

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block.

Martin RL, McDermott JS, Salmen HJ, Palmatier J, Cox BF, Gintant GA. Martin RL, et al. Among authors: gintant ga. J Cardiovasc Pharmacol. 2004 Mar;43(3):369-79. doi: 10.1097/00005344-200403000-00007. J Cardiovasc Pharmacol. 2004. PMID: 15076220

4

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.

Diaz GJ, Daniell K, Leitza ST, Martin RL, Su Z, McDermott JS, Cox BF, Gintant GA. Diaz GJ, et al. Among authors: gintant ga. J Pharmacol Toxicol Methods. 2004 Nov-Dec;50(3):187-99. doi: 10.1016/j.vascn.2004.04.001. J Pharmacol Toxicol Methods. 2004. PMID: 15519905

5

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.

Su Z, Chen J, Martin RL, McDermott JS, Cox BF, Gopalakrishnan M, Gintant GA. Su Z, et al. Among authors: gintant ga. Biochem Pharmacol. 2006 Jan 12;71(3):278-86. doi: 10.1016/j.bcp.2005.10.047. Epub 2005 Dec 1. Biochem Pharmacol. 2006. PMID: 16325148

6

Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety.

Gintant GA, Su Z, Martin RL, Cox BF. Gintant GA, et al. Toxicol Pathol. 2006;34(1):81-90. doi: 10.1080/01926230500431376. Toxicol Pathol. 2006. PMID: 16507548

7

Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels.

Limberis JT, Su Z, Cox BF, Gintant GA, Martin RL. Limberis JT, et al. Among authors: gintant ga. Clin Exp Pharmacol Physiol. 2006 Nov;33(11):1059-65. doi: 10.1111/j.1440-1681.2006.04487.x. Clin Exp Pharmacol Physiol. 2006. PMID: 17042915

8

In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience.

Martin RL, Su Z, Limberis JT, Palmatier JD, Cowart MD, Cox BF, Gintant GA. Martin RL, et al. Among authors: gintant ga. J Cardiovasc Pharmacol. 2006 Nov;48(5):199-206. doi: 10.1097/01.fjc.0000246853.15926.d4. J Cardiovasc Pharmacol. 2006. PMID: 17110801

9

Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay.

Mikhail A, Fischer C, Patel A, Long MA, Limberis JT, Martin RL, Cox BF, Gintant GA, Su Z. Mikhail A, et al. Among authors: gintant ga. J Cardiovasc Pharmacol. 2007 May;49(5):269-74. doi: 10.1097/FJC.0b013e318036dd05. J Cardiovasc Pharmacol. 2007. PMID: 17513944

10

Electrophysiologic characterization of a novel hERG channel activator.

Su Z, Limberis J, Souers A, Kym P, Mikhail A, Houseman K, Diaz G, Liu X, Martin RL, Cox BF, Gintant GA. Su Z, et al. Among authors: gintant ga. Biochem Pharmacol. 2009 Apr 15;77(8):1383-90. doi: 10.1016/j.bcp.2009.01.015. Epub 2009 Feb 3. Biochem Pharmacol. 2009. PMID: 19426677

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