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Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.
Int J Oncol. 2007 Sep;31(3):643-55.
Int J Oncol. 2007.
PMID: 17671693
Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells.
Gaddy VT, Barrett JT, Delk JN, Kallab AM, Porter AG, Schoenlein PV.
Gaddy VT, et al.
Clin Cancer Res. 2004 Aug 1;10(15):5215-25. doi: 10.1158/1078-0432.CCR-03-0637.
Clin Cancer Res. 2004.
PMID: 15297425
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A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance.
Samaddar JS, Gaddy VT, Duplantier J, Thandavan SP, Shah M, Smith MJ, Browning D, Rawson J, Smith SB, Barrett JT, Schoenlein PV.
Samaddar JS, et al. Among authors: gaddy vt.
Mol Cancer Ther. 2008 Sep;7(9):2977-87. doi: 10.1158/1535-7163.MCT-08-0447.
Mol Cancer Ther. 2008.
PMID: 18790778
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