Schmitt-Ulms G - Search Results

1

The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.

Watts JC, Drisaldi B, Ng V, Yang J, Strome B, Horne P, Sy MS, Yoong L, Young R, Mastrangelo P, Bergeron C, Fraser PE, Carlson GA, Mount HT, Schmitt-Ulms G, Westaway D. Watts JC, et al. EMBO J. 2007 Sep 5;26(17):4038-50. doi: 10.1038/sj.emboj.7601830. Epub 2007 Aug 16. EMBO J. 2007. PMID: 17703189 Free PMC article.

2

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities.

Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE. Gu Y, et al. J Biol Chem. 2004 Jul 23;279(30):31329-36. doi: 10.1074/jbc.M401548200. Epub 2004 Apr 30. J Biol Chem. 2004. PMID: 15123598 Free article.

3

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.

Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai T, Katayama T, Schmidt SD, Mathews PM, Schmitt-Ulms G, Fraser PE, St George-Hyslop P. Hasegawa H, et al. J Biol Chem. 2004 Nov 5;279(45):46455-63. doi: 10.1074/jbc.M406289200. Epub 2004 Aug 17. J Biol Chem. 2004. PMID: 15322109 Free article.

4

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P. Chen F, et al. Nature. 2006 Apr 27;440(7088):1208-12. doi: 10.1038/nature04667. Nature. 2006. PMID: 16641999

5

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland RP, Inzelberg R, Hampe W, Bujo H, Song YQ, Andersen OM, Willnow TE, Graff-Radford N, Petersen RC, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P. Rogaeva E, et al. Nat Genet. 2007 Feb;39(2):168-77. doi: 10.1038/ng1943. Epub 2007 Jan 14. Nat Genet. 2007. PMID: 17220890 Free PMC article.

6

The in vivo brain interactome of the amyloid precursor protein.

Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G. Bai Y, et al. Mol Cell Proteomics. 2008 Jan;7(1):15-34. doi: 10.1074/mcp.M700077-MCP200. Epub 2007 Oct 13. Mol Cell Proteomics. 2008. PMID: 17934213 Free article.

7

APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.

Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. Pardossi-Piquard R, et al. J Biol Chem. 2009 Jun 12;284(24):16298-16307. doi: 10.1074/jbc.M109.000067. Epub 2009 Apr 15. J Biol Chem. 2009. PMID: 19369254 Free PMC article.

8

TMP21 transmembrane domain regulates gamma-secretase cleavage.

Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. Pardossi-Piquard R, et al. J Biol Chem. 2009 Oct 16;284(42):28634-41. doi: 10.1074/jbc.M109.059345. Epub 2009 Aug 25. J Biol Chem. 2009. PMID: 19710022 Free PMC article.

9

Evolutionary descent of prion genes from the ZIP family of metal ion transporters.

Schmitt-Ulms G, Ehsani S, Watts JC, Westaway D, Wille H. Schmitt-Ulms G, et al. PLoS One. 2009 Sep 28;4(9):e7208. doi: 10.1371/journal.pone.0007208. PLoS One. 2009. PMID: 19784368 Free PMC article.

10

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones.

Watts JC, Huo H, Bai Y, Ehsani S, Jeon AH, Shi T, Daude N, Lau A, Young R, Xu L, Carlson GA, Williams D, Westaway D, Schmitt-Ulms G. Watts JC, et al. PLoS Pathog. 2009 Oct;5(10):e1000608. doi: 10.1371/journal.ppat.1000608. Epub 2009 Oct 2. PLoS Pathog. 2009. PMID: 19798432 Free PMC article.

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