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Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.
Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe KE, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE 3rd, Kumar V, Malhotra SV, Weigel NL, Gestwicki JE, Trepel JB, Neckers LM. Moses MA, et al. Cancer Res. 2018 Jul 15;78(14):4022-4035. doi: 10.1158/0008-5472.CAN-17-3728. Epub 2018 May 15. Cancer Res. 2018. PMID: 29764864 Free PMC article.
The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models.
Miyajima N, Tsutsumi S, Sourbier C, Beebe K, Mollapour M, Rivas C, Yoshida S, Trepel JB, Huang Y, Tatokoro M, Shinohara N, Nonomura K, Neckers L. Miyajima N, et al. Among authors: beebe k. Cancer Res. 2013 Dec 1;73(23):7022-33. doi: 10.1158/0008-5472.CAN-13-1156. Epub 2013 Oct 11. Cancer Res. 2013. PMID: 24121490 Free PMC article.
An acetylation site in the middle domain of Hsp90 regulates chaperone function.
Scroggins BT, Robzyk K, Wang D, Marcu MG, Tsutsumi S, Beebe K, Cotter RJ, Felts S, Toft D, Karnitz L, Rosen N, Neckers L. Scroggins BT, et al. Among authors: beebe k. Mol Cell. 2007 Jan 12;25(1):151-9. doi: 10.1016/j.molcel.2006.12.008. Mol Cell. 2007. PMID: 17218278 Free PMC article.
Impact of heat-shock protein 90 on cancer metastasis.
Tsutsumi S, Beebe K, Neckers L. Tsutsumi S, et al. Among authors: beebe k. Future Oncol. 2009 Jun;5(5):679-88. doi: 10.2217/fon.09.30. Future Oncol. 2009. PMID: 19519207 Free PMC article. Review.
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, Piper PW, Prodromou C, Pearl LH, Neckers L. Mollapour M, et al. Among authors: beebe k. Mol Cell. 2010 Feb 12;37(3):333-43. doi: 10.1016/j.molcel.2010.01.005. Mol Cell. 2010. PMID: 20159553 Free PMC article.
206 results