Denny WA - Search Results

1

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. Spicer JA, et al. Among authors: denny wa. J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880056

2

Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs.

Spicer JA, Gamage SA, Finlay GJ, Denny WA. Spicer JA, et al. Among authors: denny wa. Bioorg Med Chem. 2002 Jan;10(1):19-29. doi: 10.1016/s0968-0896(01)00249-8. Bioorg Med Chem. 2002. PMID: 11738603

3

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.

Gamage SA, Spicer JA, Rewcastle GW, Milton J, Sohal S, Dangerfield W, Mistry P, Vicker N, Charlton PA, Denny WA. Gamage SA, et al. Among authors: denny wa. J Med Chem. 2002 Jan 31;45(3):740-3. doi: 10.1021/jm010330+. J Med Chem. 2002. PMID: 11806725

4

Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.

Palmer BD, Smaill JB, Rewcastle GW, Dobrusin EM, Kraker A, Moore CW, Steinkampf RW, Denny WA. Palmer BD, et al. Among authors: denny wa. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1931-5. doi: 10.1016/j.bmcl.2005.01.079. Bioorg Med Chem Lett. 2005. PMID: 15780636

5

Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain.

Gamage SA, Rewcastle GW, Baguley BC, Charlton PA, Denny WA. Gamage SA, et al. Among authors: denny wa. Bioorg Med Chem. 2006 Feb 15;14(4):1160-8. doi: 10.1016/j.bmc.2005.09.032. Epub 2005 Oct 10. Bioorg Med Chem. 2006. PMID: 16216514

6

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.

Smaill JB, Baker EN, Booth RJ, Bridges AJ, Dickson JM, Dobrusin EM, Ivanovic I, Kraker AJ, Lee HH, Lunney EA, Ortwine DF, Palmer BD, Quin J 3rd, Squire CJ, Thompson AM, Denny WA. Smaill JB, et al. Among authors: denny wa. Eur J Med Chem. 2008 Jun;43(6):1276-96. doi: 10.1016/j.ejmech.2007.07.016. Epub 2007 Aug 6. Eur J Med Chem. 2008. PMID: 17869387

7

A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells.

Huttunen KM, Gynther M, Huttunen J, Puris E, Spicer JA, Denny WA. Huttunen KM, et al. Among authors: denny wa. J Med Chem. 2016 Jun 23;59(12):5740-51. doi: 10.1021/acs.jmedchem.6b00190. Epub 2016 Jun 8. J Med Chem. 2016. PMID: 27253989

8

Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.

Smaill JB, Gonzales AJ, Spicer JA, Lee H, Reed JE, Sexton K, Althaus IW, Zhu T, Black SL, Blaser A, Denny WA, Ellis PA, Fakhoury S, Harvey PJ, Hook K, McCarthy FO, Palmer BD, Rivault F, Schlosser K, Ellis T, Thompson AM, Trachet E, Winters RT, Tecle H, Bridges A. Smaill JB, et al. Among authors: denny wa. J Med Chem. 2016 Sep 8;59(17):8103-24. doi: 10.1021/acs.jmedchem.6b00883. Epub 2016 Aug 22. J Med Chem. 2016. PMID: 27491023

9

Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids.

Rewcastle GW, Atwell GJ, Li ZA, Baguley BC, Denny WA. Rewcastle GW, et al. Among authors: denny wa. J Med Chem. 1991 Jan;34(1):217-22. doi: 10.1021/jm00105a034. J Med Chem. 1991. PMID: 1992120

10

Potential antitumor agents. 59. Structure-activity relationships for 2-phenylbenzimidazole-4-carboxamides, a new class of "minimal" DNA-intercalating agents which may not act via topoisomerase II.

Denny WA, Rewcastle GW, Baguley BC. Denny WA, et al. J Med Chem. 1990 Feb;33(2):814-9. doi: 10.1021/jm00164a054. J Med Chem. 1990. PMID: 2153829

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