Spicer JA - Search Results

1

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. Spicer JA, et al. J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880056

2

Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.

Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA. Spicer JA, et al. J Med Chem. 1997 Jun 6;40(12):1919-29. doi: 10.1021/jm970004n. J Med Chem. 1997. PMID: 9191970

3

5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.

Spicer JA, Finlay GJ, Baguley BC, Velea L, Graves DE, Denny WA. Spicer JA, et al. Anticancer Drug Des. 1999 Feb;14(1):37-45. Anticancer Drug Des. 1999. PMID: 10363026

4

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

Gamage SA, Spicer JA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA. Gamage SA, et al. Among authors: spicer ja. J Med Chem. 1999 Jul 1;42(13):2383-93. doi: 10.1021/jm980687m. J Med Chem. 1999. PMID: 10395479

5

Dimeric analogues of non-cationic tricyclic aromatic carboxamides are a new class of cytotoxic agents.

Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA. Spicer JA, et al. Anticancer Drug Des. 1999 Jun;14(3):281-9. Anticancer Drug Des. 1999. PMID: 10500503

6

Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs.

Spicer JA, Gamage SA, Rewcastle GW, Finlay GJ, Bridewell DJ, Baguley BC, Denny WA. Spicer JA, et al. J Med Chem. 2000 Apr 6;43(7):1350-8. doi: 10.1021/jm990423f. J Med Chem. 2000. PMID: 10753472

7

Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.

Gamage SA, Spicer JA, Finlay GJ, Stewart AJ, Charlton P, Baguley BC, Denny WA. Gamage SA, et al. Among authors: spicer ja. J Med Chem. 2001 Apr 26;44(9):1407-15. doi: 10.1021/jm0003283. J Med Chem. 2001. PMID: 11311063

8

Synthesis of tetracyclic benzodioxins as potential antitumour agents.

Spicer JA, Denny WA. Spicer JA, et al. Anticancer Drug Des. 2000 Dec;15(6):453-8. Anticancer Drug Des. 2000. PMID: 11716439

9

Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs.

Spicer JA, Gamage SA, Finlay GJ, Denny WA. Spicer JA, et al. Bioorg Med Chem. 2002 Jan;10(1):19-29. doi: 10.1016/s0968-0896(01)00249-8. Bioorg Med Chem. 2002. PMID: 11738603

10

Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.

Gamage SA, Spicer JA, Rewcastle GW, Milton J, Sohal S, Dangerfield W, Mistry P, Vicker N, Charlton PA, Denny WA. Gamage SA, et al. Among authors: spicer ja. J Med Chem. 2002 Jan 31;45(3):740-3. doi: 10.1021/jm010330+. J Med Chem. 2002. PMID: 11806725

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