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An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.
Cell. 2007 Sep 21;130(6):1108-19. doi: 10.1016/j.cell.2007.07.013.
Cell. 2007.
PMID: 17889653
Free PMC article.
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.
Silverman GA, Luke CJ, Bhatia SR, Long OS, Vetica AC, Perlmutter DH, Pak SC.
Silverman GA, et al. Among authors: long os.
Pediatr Res. 2009 Jan;65(1):10-8. doi: 10.1203/PDR.0b013e31819009b0.
Pediatr Res. 2009.
PMID: 18852689
Free PMC article.
Review.
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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.
Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, Silverman GA, Pak SC.
Gosai SJ, et al. Among authors: long os.
PLoS One. 2010 Nov 12;5(11):e15460. doi: 10.1371/journal.pone.0015460.
PLoS One. 2010.
PMID: 21103396
Free PMC article.
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Using Caenorhabditis elegans to study serpinopathies.
Long OS, Gosai SJ, Kwak JH, King DE, Perlmutter DH, Silverman GA, Pak SC.
Long OS, et al.
Methods Enzymol. 2011;499:259-81. doi: 10.1016/B978-0-12-386471-0.00013-4.
Methods Enzymol. 2011.
PMID: 21683258
Free PMC article.
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A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
Miedel MT, Graf NJ, Stephen KE, Long OS, Pak SC, Perlmutter DH, Silverman GA, Luke CJ.
Miedel MT, et al. Among authors: long os.
PLoS One. 2012;7(7):e40145. doi: 10.1371/journal.pone.0040145. Epub 2012 Jul 2.
PLoS One. 2012.
PMID: 22768338
Free PMC article.
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A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC.
Long OS, et al.
Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. Epub 2014 May 16.
Hum Mol Genet. 2014.
PMID: 24838286
Free PMC article.
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A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.
O'Reilly LP, Long OS, Cobanoglu MC, Benson JA, Luke CJ, Miedel MT, Hale P, Perlmutter DH, Bahar I, Silverman GA, Pak SC.
O'Reilly LP, et al. Among authors: long os.
Hum Mol Genet. 2014 Oct 1;23(19):5123-32. doi: 10.1093/hmg/ddu236. Epub 2014 May 16.
Hum Mol Genet. 2014.
PMID: 24838285
Free PMC article.
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