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Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis.
Caggiano TJ, Brazzale A, Ho DM, Kraml CM, Trybulski E, Chadwick CC, Chippari S, Borges-Marcucci L, Eckert A, Keith JC, Kenney T, Harnish DC. Caggiano TJ, et al. Among authors: trybulski e. J Med Chem. 2007 Nov 1;50(22):5245-8. doi: 10.1021/jm701013k. Epub 2007 Sep 29. J Med Chem. 2007. PMID: 17902637
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.
Steffan RJ, Matelan E, Ashwell MA, Moore WJ, Solvibile WR, Trybulski E, Chadwick CC, Chippari S, Kenney T, Eckert A, Borges-Marcucci L, Keith JC, Xu Z, Mosyak L, Harnish DC. Steffan RJ, et al. Among authors: trybulski e. J Med Chem. 2004 Dec 16;47(26):6435-8. doi: 10.1021/jm049194+. J Med Chem. 2004. PMID: 15588074
Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
Chadwick CC, Chippari S, Matelan E, Borges-Marcucci L, Eckert AM, Keith JC Jr, Albert LM, Leathurby Y, Harris HA, Bhat RA, Ashwell M, Trybulski E, Winneker RC, Adelman SJ, Steffan RJ, Harnish DC. Chadwick CC, et al. Among authors: trybulski e. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2543-8. doi: 10.1073/pnas.0405841102. Epub 2005 Feb 7. Proc Natl Acad Sci U S A. 2005. PMID: 15699342 Free PMC article.
Control of chronic inflammation with pathway selective estrogen receptor ligands.
Steffan RJ, Matelan E, Ashwell MA, Moore WJ, Solvibile WR, Trybulski E, Chadwick CC, Chippari S, Kenney T, Winneker RC, Eckert A, Borges-Marcucci L, Adelman SJ, Xu Z, Mosyak L, Harnish DC. Steffan RJ, et al. Among authors: trybulski e. Curr Top Med Chem. 2006;6(2):103-11. doi: 10.2174/156802606775270279. Curr Top Med Chem. 2006. PMID: 16454762 Review.
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC. Mahaney PE, et al. Among authors: trybulski ej. J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17. J Med Chem. 2008. PMID: 18557608
Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.
Heffernan GD, Coghlan RD, Manas ES, McDevitt RE, Li Y, Mahaney PE, Robichaud AJ, Huselton C, Alfinito P, Bray JA, Cosmi SA, Johnston GH, Kenney T, Koury E, Winneker RC, Deecher DC, Trybulski EJ. Heffernan GD, et al. Among authors: trybulski ej. Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. doi: 10.1016/j.bmc.2009.09.023. Epub 2009 Sep 18. Bioorg Med Chem. 2009. PMID: 19836247
43 results