Worthy KM - Search Results

1

Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.

Stephen AG, Datta SA, Worthy KM, Bindu L, Fivash MJ, Turner KB, Fabris D, Rein A, Fisher RJ. Stephen AG, et al. Among authors: worthy km. J Biomol Tech. 2007 Sep;18(4):259-66. J Biomol Tech. 2007. PMID: 17916799 Free PMC article.

2

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides.

Fisher RJ, Fivash MJ, Stephen AG, Hagan NA, Shenoy SR, Medaglia MV, Smith LR, Worthy KM, Simpson JT, Shoemaker R, McNitt KL, Johnson DG, Hixson CV, Gorelick RJ, Fabris D, Henderson LE, Rein A. Fisher RJ, et al. Among authors: worthy km. Nucleic Acids Res. 2006 Jan 24;34(2):472-84. doi: 10.1093/nar/gkj442. Print 2006. Nucleic Acids Res. 2006. PMID: 16434700 Free PMC article.

3

Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity.

Stephen AG, Worthy KM, Towler E, Mikovits JA, Sei S, Roberts P, Yang QE, Akee RK, Klausmeyer P, McCloud TG, Henderson L, Rein A, Covell DG, Currens M, Shoemaker RH, Fisher RJ. Stephen AG, et al. Among authors: worthy km. Biochem Biophys Res Commun. 2002 Sep 6;296(5):1228-37. doi: 10.1016/s0006-291x(02)02063-6. Biochem Biophys Res Commun. 2002. PMID: 12207905

4

Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles.

Oishi S, Shi ZD, Worthy KM, Bindu LK, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: worthy km. Chembiochem. 2005 Apr;6(4):668-74. doi: 10.1002/cbic.200400298. Chembiochem. 2005. PMID: 15719347

5

Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis.

Liu F, Worthy KM, Bindu L, Giubellino A, Bottaro DP, Fisher RJ, Burke TR Jr. Liu F, et al. Among authors: worthy km. Org Biomol Chem. 2007 Jan 21;5(2):367-72. doi: 10.1039/b611887a. Epub 2006 Dec 4. Org Biomol Chem. 2007. PMID: 17205182

6

A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity.

Shi ZD, Lee K, Liu H, Zhang M, Roberts LR, Worthy KM, Fivash MJ, Fisher RJ, Yang D, Burke TR Jr. Shi ZD, et al. Among authors: worthy km. Biochem Biophys Res Commun. 2003 Oct 17;310(2):378-83. doi: 10.1016/j.bbrc.2003.09.029. Biochem Biophys Res Commun. 2003. PMID: 14521921

7

Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.

Kang SU, Shi ZD, Worthy KM, Bindu LK, Dharmawardana PG, Choyke SJ, Bottaro DP, Fisher RJ, Burke TR Jr. Kang SU, et al. Among authors: worthy km. J Med Chem. 2005 Jun 16;48(12):3945-8. doi: 10.1021/jm050059m. J Med Chem. 2005. PMID: 15943469

8

Design and synthesis of 4-(alpha-hydroxymalonyl)phenylalanine as a new phosphotyrosyl mimetic and its use in growth factor receptor bound 2 src-homology 2 (Grb2 SH2) domain-binding peptides.

Kang SU, Worthy KM, Bindu LK, Zhang M, Yang D, Fisher RJ, Burke TR Jr. Kang SU, et al. Among authors: worthy km. J Med Chem. 2005 Aug 11;48(16):5369-72. doi: 10.1021/jm050154v. J Med Chem. 2005. PMID: 16078854

9

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR Jr. Choi WJ, et al. Among authors: worthy km. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265-9. doi: 10.1016/j.bmcl.2006.08.004. Bioorg Med Chem Lett. 2006. PMID: 16908148 Free PMC article.

10

Utilization of a common pathway for the synthesis of high affinity macrocyclic Grb2 SH2 domain-binding peptide mimetics that differ in the configuration at one ring junction.

Shi ZD, Karki RG, Worthy KM, Bindu LK, Nicklaus MC, Fisher RJ, Burke TR Jr. Shi ZD, et al. Among authors: worthy km. Chem Biodivers. 2005 Apr;2(4):447-56. doi: 10.1002/cbdv.200590024. Chem Biodivers. 2005. PMID: 17191992

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