Nielsen UB - Search Results

1

A data-driven computational model of the ErbB receptor signaling network.

Schoeberl B, Pace E, Howard S, Garantcharova V, Kudla A, Sorger PK, Nielsen UB. Schoeberl B, et al. Among authors: nielsen ub. Conf Proc IEEE Eng Med Biol Soc. 2006;2006:53-4. doi: 10.1109/IEMBS.2006.259754. Conf Proc IEEE Eng Med Biol Soc. 2006. PMID: 17946779

2

Profiling receptor tyrosine kinase activation by using Ab microarrays.

Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Nielsen UB, et al. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9330-5. doi: 10.1073/pnas.1633513100. Epub 2003 Jul 22. Proc Natl Acad Sci U S A. 2003. PMID: 12876202 Free PMC article.

3

Systems biology and combination therapy in the quest for clinical efficacy.

Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Fitzgerald JB, et al. Among authors: nielsen ub. Nat Chem Biol. 2006 Sep;2(9):458-66. doi: 10.1038/nchembio817. Nat Chem Biol. 2006. PMID: 16921358

4

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.

Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Chen WW, et al. Among authors: nielsen ub. Mol Syst Biol. 2009;5:239. doi: 10.1038/msb.2008.74. Epub 2009 Jan 20. Mol Syst Biol. 2009. PMID: 19156131 Free PMC article.

5

Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.

Schoeberl B, Pace EA, Fitzgerald JB, Harms BD, Xu L, Nie L, Linggi B, Kalra A, Paragas V, Bukhalid R, Grantcharova V, Kohli N, West KA, Leszczyniecka M, Feldhaus MJ, Kudla AJ, Nielsen UB. Schoeberl B, et al. Among authors: nielsen ub. Sci Signal. 2009 Jun 30;2(77):ra31. doi: 10.1126/scisignal.2000352. Sci Signal. 2009. PMID: 19567914

6

Optimizing properties of antireceptor antibodies using kinetic computational models and experiments.

Harms BD, Kearns JD, Su SV, Kohli N, Nielsen UB, Schoeberl B. Harms BD, et al. Among authors: nielsen ub. Methods Enzymol. 2012;502:67-87. doi: 10.1016/B978-0-12-416039-2.00004-5. Methods Enzymol. 2012. PMID: 22208982

7

Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).

Schoeberl B, Kudla A, Masson K, Kalra A, Curley M, Finn G, Pace E, Harms B, Kim J, Kearns J, Fulgham A, Burenkova O, Grantcharova V, Yarar D, Paragas V, Fitzgerald J, Wainszelbaum M, West K, Mathews S, Nering R, Adiwijaya B, Garcia G, Kubasek B, Moyo V, Czibere A, Nielsen UB, MacBeath G. Schoeberl B, et al. Among authors: nielsen ub. NPJ Syst Biol Appl. 2017 Jan 5;3:16034. doi: 10.1038/npjsba.2016.34. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28725482 Free PMC article. Review.

8

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer.

Camblin AJ, Pace EA, Adams S, Curley MD, Rimkunas V, Nie L, Tan G, Bloom T, Iadevaia S, Baum J, Minx C, Czibere A, Louis CU, Drummond DC, Nielsen UB, Schoeberl B, Pipas JM, Straubinger RM, Askoxylakis V, Lugovskoy AA. Camblin AJ, et al. Among authors: nielsen ub. Clin Cancer Res. 2018 Jun 15;24(12):2873-2885. doi: 10.1158/1078-0432.CCR-17-2262. Epub 2018 Mar 16. Clin Cancer Res. 2018. PMID: 29549161

9

The response of human epithelial cells to TNF involves an inducible autocrine cascade.

Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. Janes KA, et al. Among authors: nielsen ub. Cell. 2006 Mar 24;124(6):1225-39. doi: 10.1016/j.cell.2006.01.041. Cell. 2006. PMID: 16564013 Free article.

10

An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation.

Schoeberl B, Faber AC, Li D, Liang MC, Crosby K, Onsum M, Burenkova O, Pace E, Walton Z, Nie L, Fulgham A, Song Y, Nielsen UB, Engelman JA, Wong KK. Schoeberl B, et al. Among authors: nielsen ub. Cancer Res. 2010 Mar 15;70(6):2485-94. doi: 10.1158/0008-5472.CAN-09-3145. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215504 Free PMC article.

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