Grembecka J - Search Results

1

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Skinner-Adams TS, Lowther J, Teuscher F, Stack CM, Grembecka J, Mucha A, Kafarski P, Trenholme KR, Dalton JP, Gardiner DL. Skinner-Adams TS, et al. Among authors: grembecka j. J Med Chem. 2007 Nov 29;50(24):6024-31. doi: 10.1021/jm070733v. Epub 2007 Oct 26. J Med Chem. 2007. PMID: 17960925

2

Computer-aided design and activity prediction of leucine aminopeptidase inhibitors.

Grembecka J, Sokalski WA, Kafarski P. Grembecka J, et al. J Comput Aided Mol Des. 2000 Aug;14(6):531-44. doi: 10.1023/a:1008189716955. J Comput Aided Mol Des. 2000. PMID: 10921770

3

Leucine aminopeptidase as a target for inhibitor design.

Grembecka J, Kafarski P. Grembecka J, et al. Mini Rev Med Chem. 2001 Jul;1(2):133-44. doi: 10.2174/1389557013406990. Mini Rev Med Chem. 2001. PMID: 12369979 Review.

4

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.

Grembecka J, Mucha A, Cierpicki T, Kafarski P. Grembecka J, et al. J Med Chem. 2003 Jun 19;46(13):2641-55. doi: 10.1021/jm030795v. J Med Chem. 2003. PMID: 12801228

5

alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases.

Drag M, Grembecka J, Pawełczak M, Kafarski P. Drag M, et al. Among authors: grembecka j. Eur J Med Chem. 2005 Aug;40(8):764-71. doi: 10.1016/j.ejmech.2005.02.011. Epub 2005 Apr 20. Eur J Med Chem. 2005. PMID: 16122579

6

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity.

Białas A, Grembecka J, Krowarsch D, Otlewski J, Potempa J, Mucha A. Białas A, et al. Among authors: grembecka j. J Med Chem. 2006 Mar 9;49(5):1744-53. doi: 10.1021/jm0600141. J Med Chem. 2006. PMID: 16509589

7

A phosphonamidate containing aromatic N-terminal amino group as inhibitor of leucine aminopeptidase-design, synthesis and stability.

Mucha A, Kunert A, Grembecka J, Pawełczak M, Kafarski P. Mucha A, et al. Among authors: grembecka j. Eur J Med Chem. 2006 Jun;41(6):768-72. doi: 10.1016/j.ejmech.2006.03.023. Epub 2006 May 11. Eur J Med Chem. 2006. PMID: 16690170

8

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.

Stack CM, Lowther J, Cunningham E, Donnelly S, Gardiner DL, Trenholme KR, Skinner-Adams TS, Teuscher F, Grembecka J, Mucha A, Kafarski P, Lua L, Bell A, Dalton JP. Stack CM, et al. Among authors: grembecka j. J Biol Chem. 2007 Jan 19;282(3):2069-80. doi: 10.1074/jbc.M609251200. Epub 2006 Nov 15. J Biol Chem. 2007. PMID: 17107951 Free article.

9

A synthetic method for diversification of the P1' substituent in phosphinic dipeptides as a tool for exploration of the specificity of the S1' binding pockets of leucine aminopeptidases.

Vassiliou S, Xeilari M, Yiotakis A, Grembecka J, Pawełczak M, Kafarski P, Mucha A. Vassiliou S, et al. Among authors: grembecka j. Bioorg Med Chem. 2007 May 1;15(9):3187-200. doi: 10.1016/j.bmc.2007.02.042. Epub 2007 Feb 22. Bioorg Med Chem. 2007. PMID: 17337192

10

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.

McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. McGowan S, et al. Among authors: grembecka j. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2537-42. doi: 10.1073/pnas.0807398106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196988 Free PMC article.

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