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Activation of the lytic program of the Epstein-Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent.
Oussaief L, Hippocrate A, Clybouw C, Rampanou A, Ramirez V, Desgranges C, Vazquez A, Khelifa R, Joab I. Oussaief L, et al. Virology. 2009 Apr 25;387(1):41-9. doi: 10.1016/j.virol.2009.02.009. Epub 2009 Feb 28. Virology. 2009. PMID: 19254802 Free article.
Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation.
Oussaief L, Hippocrate A, Ramirez V, Rampanou A, Zhang W, Meyers D, Cole P, Khelifa R, Joab I. Oussaief L, et al. J Biol Chem. 2009 Sep 4;284(36):23912-24. doi: 10.1074/jbc.M109.036483. Epub 2009 Jul 9. J Biol Chem. 2009. PMID: 19589780 Free PMC article.