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Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.
Hu B, Jetter J, Kaufman D, Singhaus R, Bernotas R, Unwalla R, Quinet E, Savio D, Halpern A, Basso M, Keith J, Clerin V, Chen L, Liu QY, Feingold I, Huselton C, Azam F, Goos-Nilsson A, Wilhelmsson A, Nambi P, Wrobel J. Hu B, et al. Among authors: jetter j. Bioorg Med Chem. 2007 May 15;15(10):3321-33. doi: 10.1016/j.bmc.2007.03.013. Epub 2007 Mar 12. Bioorg Med Chem. 2007. PMID: 17391964
Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.
Ullrich JW, Morris R, Bernotas RC, Travins JM, Jetter J, Unwalla R, Quinet E, Nambi P, Feingold I, Huselton C, Enroth C, Wilhelmsson A, Goos-Nilsson A, Wrobel J. Ullrich JW, et al. Among authors: jetter j. Bioorg Med Chem Lett. 2010 May 1;20(9):2903-7. doi: 10.1016/j.bmcl.2010.03.031. Epub 2010 Mar 9. Bioorg Med Chem Lett. 2010. PMID: 20382019
Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
Pelletier JC, Chengalvala MV, Cottom JE, Feingold IB, Green DM, Hauze DB, Huselton CA, Jetter JW, Kopf GS, Lundquist JT, Magolda RL, Mann CW, Mehlmann JF, Rogers JF, Shanno LK, Adams WR, Tio CO, Wrobel JE. Pelletier JC, et al. J Med Chem. 2009 Apr 9;52(7):2148-52. doi: 10.1021/jm801572m. J Med Chem. 2009. PMID: 19271735
2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.
Pelletier JC, Chengalvala M, Cottom J, Feingold I, Garrick L, Green D, Hauze D, Huselton C, Jetter J, Kao W, Kopf GS, Lundquist JT 4th, Mann C, Mehlmann J, Rogers J, Shanno L, Wrobel J. Pelletier JC, et al. Among authors: jetter j. Bioorg Med Chem. 2008 Jul 1;16(13):6617-40. doi: 10.1016/j.bmc.2008.05.024. Epub 2008 May 11. Bioorg Med Chem. 2008. PMID: 18511284
Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).
Pitts WJ, Wityak J, Smallheer JM, Tobin AE, Jetter JW, Buynitsky JS, Harlow PP, Solomon KA, Corjay MH, Mousa SA, Wexler RR, Jadhav PK. Pitts WJ, et al. Among authors: jetter jw. J Med Chem. 2000 Jan 13;43(1):27-40. doi: 10.1021/jm9900321. J Med Chem. 2000. PMID: 10633036
39 results