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Page 1
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.
Yoshikawa K, Yokomizo A, Naito H, Haginoya N, Kobayashi S, Yoshino T, Nagata T, Mochizuki A, Osanai K, Watanabe K, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: ohta t. Bioorg Med Chem. 2009 Dec 15;17(24):8206-20. doi: 10.1016/j.bmc.2009.10.023. Epub 2009 Oct 31. Bioorg Med Chem. 2009. PMID: 19884015
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Yoshikawa K, Kobayashi S, Nakamoto Y, Haginoya N, Komoriya S, Yoshino T, Nagata T, Mochizuki A, Watanabe K, Suzuki M, Kanno H, Ohta T. Yoshikawa K, et al. Among authors: ohta t. Bioorg Med Chem. 2009 Dec 15;17(24):8221-33. doi: 10.1016/j.bmc.2009.10.024. Epub 2009 Oct 17. Bioorg Med Chem. 2009. PMID: 19900814
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety.
Nakayama K, Kuru N, Ohtsuka M, Yokomizo Y, Sakamoto A, Kawato H, Yoshida K, Ohta T, Hoshino K, Akimoto K, Itoh J, Ishida H, Cho A, Palme MH, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2004 May 17;14(10):2493-7. doi: 10.1016/j.bmcl.2004.03.007. Bioorg Med Chem Lett. 2004. PMID: 15109639
MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida Ki, Yokomizo Y, Hosono S, Ohta T, Hoshino K, Ishida H, Yoshida K, Renau TE, Léger R, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4201-4. doi: 10.1016/j.bmcl.2003.07.024. Bioorg Med Chem Lett. 2003. PMID: 14623001
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida K, Yokomizo Y, Ohta T, Hoshino K, Otani T, Kurosaka Y, Yoshida K, Ishida H, Lee VJ, Renau TE, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4205-8. doi: 10.1016/j.bmcl.2003.07.027. Bioorg Med Chem Lett. 2003. PMID: 14623002
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model.
Nakayama K, Kawato H, Watanabe J, Ohtsuka M, Yoshida K, Yokomizo Y, Sakamoto A, Kuru N, Ohta T, Hoshino K, Yoshida K, Ishida H, Cho A, Palme MH, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: ohta t. Bioorg Med Chem Lett. 2004 Jan 19;14(2):475-9. doi: 10.1016/j.bmcl.2003.10.060. Bioorg Med Chem Lett. 2004. PMID: 14698185
3,578 results