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Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia.
le Coutre P, Ottmann OG, Giles F, Kim DW, Cortes J, Gattermann N, Apperley JF, Larson RA, Abruzzese E, O'Brien SG, Kuliczkowski K, Hochhaus A, Mahon FX, Saglio G, Gobbi M, Kwong YL, Baccarani M, Hughes T, Martinelli G, Radich JP, Zheng M, Shou Y, Kantarjian H. le Coutre P, et al. Among authors: apperley jf. Blood. 2008 Feb 15;111(4):1834-9. doi: 10.1182/blood-2007-04-083196. Epub 2007 Nov 29. Blood. 2008. PMID: 18048643 Free article. Clinical Trial.
Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia.
Olavarria E, Kanfer E, Szydlo R, Kaeda J, Rezvani K, Cwynarski K, Pocock C, Dazzi F, Craddock C, Apperley JF, Cross NC, Goldman JM. Olavarria E, et al. Among authors: apperley jf. Blood. 2001 Mar 15;97(6):1560-5. doi: 10.1182/blood.v97.6.1560. Blood. 2001. PMID: 11238091 Free article.
Not so NICE for CML.
Goldman J, Apperley J, Clark R, Green T, Holyoake T, O'Brien S, Shepherd P. Goldman J, et al. Lancet. 2002 Jun 8;359(9322):2036. doi: 10.1016/S0140-6736(02)08796-2. Lancet. 2002. PMID: 12076575 No abstract available.
Chronic myeloid leukemia.
Melo JV, Hughes TP, Apperley JF. Melo JV, et al. Among authors: apperley jf. Hematology Am Soc Hematol Educ Program. 2003:132-52. doi: 10.1182/asheducation-2003.1.132. Hematology Am Soc Hematol Educ Program. 2003. PMID: 14633780 Free article. Review.
Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT.
Crawley C, Szydlo R, Lalancette M, Bacigalupo A, Lange A, Brune M, Juliusson G, Nagler A, Gratwohl A, Passweg J, Komarnicki M, Vitek A, Mayer J, Zander A, Sierra J, Rambaldi A, Ringden O, Niederwieser D, Apperley JF; Chronic Leukemia Working Party of the EBMT. Crawley C, et al. Among authors: apperley jf. Blood. 2005 Nov 1;106(9):2969-76. doi: 10.1182/blood-2004-09-3544. Epub 2005 Jul 5. Blood. 2005. PMID: 15998838 Free article.
501 results