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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
Nomeir AA, Pramanik BN, Heimark L, Bennett F, Veals J, Bartner P, Hilbert M, Saksena A, McNamara P, Girijavallabhan V, Ganguly AK, Lovey R, Pike R, Wang H, Liu YT, Kumari P, Korfmacher W, Lin CC, Cacciapuoti A, Loebenberg D, Hare R, Miller G, Pickett C. Nomeir AA, et al. Among authors: cacciapuoti a. J Mass Spectrom. 2008 Apr;43(4):509-17. doi: 10.1002/jms.1341. J Mass Spectrom. 2008. PMID: 18059003
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
Bennett F, Saksena AK, Lovey RG, Liu YT, Patel NM, Pinto P, Pike R, Jao E, Girijavallabhan VM, Ganguly AK, Loebenberg D, Wang H, Cacciapuoti A, Moss E, Menzel F, Hare RS, Nomeir A. Bennett F, et al. Among authors: cacciapuoti a. Bioorg Med Chem Lett. 2006 Jan 1;16(1):186-90. doi: 10.1016/j.bmcl.2005.09.031. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16260134
Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis.
Patera AC, Menzel F, Jackson C, Brieland JK, Halpern J, Hare R, Cacciapuoti A, Loebenberg D. Patera AC, et al. Among authors: cacciapuoti a. Antimicrob Agents Chemother. 2004 Aug;48(8):3154-8. doi: 10.1128/AAC.48.8.3154-3158.2004. Antimicrob Agents Chemother. 2004. PMID: 15273138 Free PMC article.
In vitro and in vivo activities of SCH 56592 (posaconazole), a new triazole antifungal agent, against Aspergillus and Candida.
Cacciapuoti A, Loebenberg D, Corcoran E, Menzel F Jr, Moss EL Jr, Norris C, Michalski M, Raynor K, Halpern J, Mendrick C, Arnold B, Antonacci B, Parmegiani R, Yarosh-Tomaine T, Miller GH, Hare RS. Cacciapuoti A, et al. Antimicrob Agents Chemother. 2000 Aug;44(8):2017-22. doi: 10.1128/AAC.44.8.2017-2022.2000. Antimicrob Agents Chemother. 2000. PMID: 10898669 Free PMC article.
55 results